COMPARATIVE STUDY ON EFFECT OF SOLID DISPERSION TECHNIQUES FOR ENHANCEMENT OF DISSOLUTION RATE OF PIOGLITAZONE HCl
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 8
Abstract
Pioglitazone hydrochloride is a novel antidiabetic drug in thiazolidinediones group and it improves insulin sensitivity in insulin resistant patients. One of the major problems with this drug is its low solubility in biological fluids, which results into poor bioavailability after oral administration. The present study is an attempt to enhance the dissolution rate of pioglitazone HCl by kneading and physical mixture techniques using pioglitazone HCl and β-cyclodextrine as carrier in the ratios of 1:1, 1:2 and 1:3 respectively. The drug carrier interaction study was carried out by Fourier Transform Infrared Spectroscopy (FTIR). The prepared solid dispersions were characterized for percentage yield, bulk density, tapped density, Carr’s Index, Hausner’s ratio, angle of repose, drug content, drug dissolution and stability study. The FTIR study suggesting no interaction between drug and carrier of solid dispersion. The kneading and physical mixture techniques were found to be efficient method to obtained good yield solid dispersions with good flow properties. The drug content was found in the ranges of 77.2±0.28 to 88.8±0.19 %. Dissolution study revealed that there is marked enhancement in the dissolution rate of pioglitazone from all the solid dispersions when compared to pure pioglitazone itself. From the in vitro drug release profile, it can be seen that formulation F1 (1:1 ratio of drug: β-cyclodextrine, prepared by kneading technique) shows higher dissolution rate compared with other formulations. All pioglitazone solid dispersions were found to be stable in various storage temperatures. The kneading is suitable method for development of solid dispersion of pioglitazone HCl.
Authors and Affiliations
Sruti Mishra , Ellaiah P. , Prabhat Jena , Bhabani Nayak , Gitanjali Mishra
Keywords
Related Articles
- EP ID EP103285
- DOI -
- Views 158
- Downloads 0
ANTIOXIDANTS OF CLOVE (SYZYGIUM AROMATICUM) PREVENT METAL INDUCED OXIDATIVE DAMAGE OF BIOMOLECULES
The present study evaluates the antioxidant potential of clove against copper induced lipid peroxidation, protein oxidative modifications and iron induced damage to DNA. 1, 1-diphenyl1-2 picryl hydrazyl free radical scav...
A NOVEL FLOATING DRUG DELIVERY SYSTEM
Drugs with narrow absorption window in the gastrointestinal tract have poor absorption. Therefore, gastroretentive drug delivery systems (GRDDS) have been developed, which prolong the gastric emptying time. Several techn...
EVALUATION OF ANTIMICROBIAL AND ANTI-HISTAMINE ACTIVITY OF THE AERIAL PARTS OF TEPHROSIA PURPUREA L.
Tephrosia purpurea (Fabaceae) has been used as a medicinal plant in all over India. This plant is a much branched perennial herb. Roots are given orally against any type of poisoning such as snakebite and the aerial part...
CURRENT TRENDS IN DRUG DISCOVERY: TARGET IDENTIFICATION TO CLINICAL DEVELOPMENT OF THE DRUG
The practice of the drug discovery process has been revolutionized with the involvement of some newer techniques. Target based drug design is more advantageous, time consuming and effective. With the use of High Throughp...
COLLOID MEDIATED DRUG TRANSPORT ACROSS DERMAL ROUTE: A CRITICAL REVIEW
Pressure techniques or Focussed forces like sonic pulses, voltage pulses, ballistic treatment or optoporation by Laser beam and use of penetration enhancers are more often invasive to overcome the multiple barrier functi...