COMPARATIVE STUDY ON EFFICACY & SAFETY OF INTRAVENOUS IRON SUCROSE VERSUS INTRAMUSCULAR IRON SORBITOL THERAPY IN ANEMIA DURING PREGNANCY
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2013, Vol 2, Issue 4
Abstract
Aims and Objectives: To compare the efficacy, safety, and rate of response of intravenous iron sucrose and intramuscular iron Sorbitol therapy for anemia during pregnancy. Material and Methods: 100 antenatal cases of gestational age 16-32 weeks were included in this prospective study. Cases were randomly divided into two groups. Group A, having 50 cases received intravenous iron sucrose, and 50cases in group B received intramuscular iron sorbitol. Response to therapy in both groups was studied and compared. Results: The mean pretherapy hemoglobin in group A was 6.49 g/dl and in group B was 6.48 g/dl. The rise in hemoglobin after 4 weeks of starting therapy was 3.52 g/dl in group A and 2.33 g/dl in group B The difference was Statistically significant (P<0.01) The mean time taken to achieve target hemoglobin (>11 g/dl) was 6.37 weeks in group A and 9.04 weeks in group B. In group A, 8% (four) cases had grade I adverse effects. In group B, 24% (12) cases had grade I adverse effects. The difference was statistically significant (P=0.027). In both the groups no case discontinued the therapy. Conclusion: Intravenous iron sucrose is safe, convenient, more effective, and faster acting therapy than intramuscular iron sorbitol therapy for treating moderate to severe anemia during pregnancy.
Authors and Affiliations
Lomte DB| Asso. Prof, Dept. of Pharmacology, Dr. V.P.M.C. Nashik, Maharashtra, India Corresponding author email: rahulbraje@gmail.com, vasantjamdhade@gmail.com, Bhosale RS| Civil Hospital Nashik, Dept., OBGY, Civil Hospital Nashik, Maharashtra, India, Jambdade V| Head of Dept., OBGY, Civil Hospital Nashik, Maharashtra, India, Gore PR| Civil Hospital Nashik, Dept., OBGY, Civil Hospital Nashik, Maharashtra, India
Keywords
Related Articles
- EP ID EP11047
- DOI 10.5958/j.2319-5886.2.4.115
- Views 335
- Downloads 22
OSSIFYING RETROPERITONEAL CYSTIC LYMPHANGIOMA IN A PREGNANT WOMAN
Retroperitoneal cystic lymphangiomas are very rare lesions and may be misdiagnosed. Longstanding lymphangiomas may show secondary changes like inflammation, hemorrhage, fibrosis and rarely ossification. Treatment is co...
Prevalence of antibiotic sensitivity pattern of uropathogens in patients of different age-groups from western region of Nepal
UTI, the most common bacterial infection in urinary tract, is a serious health- problem that occurs in millions of people at any age in each year. Its empirical treatment is difficult worldwide. Local susceptibility-pat...
Prevalence of sexual dysfunction among women using contraceptive methods
Introduction: The world health organization defines sexual health as a coordination and integration between mind, body and feelings which leads an individual towards personality improvement, relationship and love. The a...
ACUTE TOXICOLOGICAL EVALUATION OF PET – ETHER EXTRACT OF PORTULACA OLERACEA (LINN.) ON RODENTS
Introduction: Portulaca oleracea is a common plant used in south Indian culinary; recently there is increase in research publication on various biological activities of the medicinal herb. The safety of the medicinal h...
Role of Bronchoscopy in Malignant Pleural effusion
The aim of this study was to assess the role of Bronchoscopy in plural effusion in cancer condition. Pleural effusion is one of the commonest problems with which patients present to the hospital. Around a million patien...