Comparative Study to Assess Clinical Efficacy of Leukotriene Receptor Antagonist and Antihistamines in the Treatment of Allergic Rhinitis
Journal Title: Bengal Journal of Otolaryngology and Head Neck Surgery - Year 2017, Vol 25, Issue 2
Abstract
Introduction Pharmacologic treatment options for allergic rhinitis include intranasal corticosteroids, oral and topical antihistamines, decongestants, intranasal cromolyn, intranasal anticholinergics and leukotriene receptor antagonists. The present study was undertaken to compare the efficacy of leukotriene receptor antagonist and antihistamines in relieving nasal congestion/ obstruction symptom and itching /irritation in eyes.Material and Methods The study was conducted among 125 patients clinically diagnosed suffering from allergic rhinitis Patients were divided into 5 groups and were given oral treatment with oral antihistamines (chlorpheniramine maleate, levocetrizine, fexofenadine, desloratadine) and leukotriene receptor antagonist (montelukast) for a period of 6 weeks. The results were tabulated and analyzed by Chi-square and Kruskal-Wallis test with p value <0.05 as significant value.ResultFor relieving nasal obstruction, levocetrizine group showed maximum improvement at 2 weeks. However, at the end of 6 weeks montelukast group showed maximum relief followed by levocetrizine and desloratidine. In relieving eye itching/irritation, montelukast and levocetirizine were equally effective. Fexofenadine and desloratadine were less effective in relieving nasal obstruction and eye itching/irritation followed by chlorpheniramine maleate, which was least effective.ConclusionAllergic rhinitis affects the social and professional life of patient. Allergen avoidance should be the initial step in the management of allergic rhinitis. Montelukast and levocetirizine are more effective in relieving nasal obstruction and eye itching/irritation compared to fexofenadine, desloratadine and chlorpheniramine maleate.
Authors and Affiliations
Gurpreet Kaur, Rachna Dhingra, Manjinder Singh
Keywords
Related Articles
- EP ID EP433959
- DOI -
- Views 38
- Downloads 0
Large Neurilemmoma of Buccal Mucosa in a Child – A Rare Entity
Abstract:Introduction: Neurilemmoma or Schwannomas are benign tumour arising from the nerve sheath of myelinated nerve. Head neck neurilemmomas are not uncommon but intraoral region is very uncommon for this type of tumo...
Role of Polidocanol as Sclerosant in Treatment of Hemangiomas of Head and Neck Region
IntroductionHaemangiomas are common presentation in head and neck, prevalence being 60% followed by 25% and 15% respectively in trunk and limbs. This report studies the efficacy of Polidocanol as sclerosant in the treatm...
A Comparative Study of Conventional versus Endoscopic Septoplasty
IntroductionThe standard surgical treatment for symptomatic deviated septum is septoplasty. This is usually done conventionally using the headlight. However, in recent years the endoscopic method has emerged as an altern...
Aberrant Thyroid in the Parapharyngeal Space
Introduction Aberrant thyroid is a mass of tissue having the structure of a normal or pathological thyroid gland and situated at some definite distance from normal thyroid, with which it has no connection. The prevalance...
Intralesional Sclerotherapy with Polidocanol in the Management of Head and Neck Vascular Lesions
IntroductionVascular lesions (Hemangioma or vascular malformation) in the head and neck region are quite common and need therapeutic intervention if they become symptomatic or cosmetically unacceptable. Different therap...