Comparing the adverse impact of Ethanolic Root Bark and Leaf Extracts of Rauwofiavomitoria(apocynaceae) on Cerebellar Glycogen in Adult Wistar Rats
Journal Title: Saudi Journal of Medical and Pharmaceutical Sciences - Year 2017, Vol 3, Issue 9
Abstract
Abstract:The use of herbal medicine in Nigeria is on the increase but unknowingly to consumers, these herbal products may pose severe and devastating health hazards. This study was aimed at studying the adverse impacts posed by either the ethanolic extract ofroot back or leaf extract of Rauwofiavomitoria on cerebellar glycogen. In this study, 30 adult Wistar rats were used and were randormly divided into 6 groups (A, B, C, D and E; n =5). Identification of Glycogen was determined using Periodic Acid Schiff method (PAS). From this investigation, there was a marked increase in the staining intensities of the experimental groups. The staining intensity of PAS was higher in the groups C and D which were given 200mg/kg and 300mg/kg of ethanolic extract of Rauwofiavomitoria root-bark when compared to groups E and F which received 200mg/kg and 300mg/kg of ethanolic leaf extract of Rauwofiavomitoria. Findings in this study suggest a dose-dependent accumulation of glycogen in the neurons of cerebellum, especially in the Purkinje cells. This could be due to the effects of indole alkaloid constituents (reserpine) of Rauwolfiavomitoria on glycogen synthesis and utilization. Keywords:PAS, Rauwofiavomitoria, cerebellum, glycogen, root bark, leaf extract
Authors and Affiliations
Akaninyene M. Okon, Clementina F. Iniodu, Gabriel D. Edem, Ekaette P. Akpan
Keywords
Related Articles
- EP ID EP391799
- DOI -
- Views 75
- Downloads 0
Comparative Study of Efficacy of Piperacillin/ Tazobactam and Cefoperazone/ Sulbactam Combinations in Hospitalised Patients of Complicated Urinary Tract Infections
Complicated UTIs (cUTIs) are one of the leading causes of the gram negative bacteraemia which occur in patients who have a functionally, metabolically, or anatomically abnormal urinary tract. The primary objective of thi...
Evaluation/Comprehension of Prescription Writing in V.S General Hospital and Nagri Eye Hospital
Abstract: Improper comprehension of the prescription can lead to wrong drugs taken, misuse of the drug dosage, and ineffective drug action by not following the proper schedule, which was advised, or development of advers...
Lower Eyelid Reconstruction Using Prelaminated Nasolabial Flap: A Revisited Surgical Technique
We present the lower eyelid reconstruction using prelaminated nasolabial skin flap in a 28- year old albino, who presented with medial third lower eyelid lesion with a histopathologically proven basosquamous carcinoma. W...
Comparative Study of Effect of Farming on Anthropological Parameters among Farmers and Non-farmers
Abstract: In most countries, agriculture is recognized as one of the most hazardous industries. Investigating the health status of agricultural workers is a challenging goal. The aim of this study was to examine the impa...
Optimization of Self Micro Emulsifying Drug Delivery System Containing Curcumin and Artemisinin Using D-Optimal Mixture Design
Abstract: Curcumin and Artemisininare a poorly water-soluble drugs and its poor oral bioavailability is very low. A new self-micro emulsifying drug delivery system (SMEDDS) has been magnificently developed to improve the...