Comparism of Antioxidants Status among Children, Teenagers and Adults with Sickle Cell Anaemia.

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Comparism of Antioxidants Status among Children, Teenagers and Adults with Sickle Cell Anaemia.

Journal Title: International Journal of Engineering and Science Invention - Year 2017, Vol 6, Issue 7

Abstract

Background: One of the diseases caused by a mutation in a gene is sickle cell anaemia. Sickle cell anaemia is a serious disorder in which the body makes sickle-shaped red blood cells. The sickle cells block blood flow in the blood vessels, this causes pain as well as organ damage, and it can also raise the risk of infection. Materials and methods: This study was carried out to determine, as well as compare, the activities of enzymatic antioxidants- Glutathione peroxidase (GPx), Catalase (Cat) and Superoxide dismutase (SOD), as well as some non- enzymatic antioxidants (Vitamins C and E ), in the plasma of sickle cell , non-sickle cell and sickle cell trait children, teenagers and adults. Sixty adults were grouped into 3 groups of 20 subjects each; the groups were having the status of AA, AS, and SS respectively. The same grouping arrangement was made for 60 teenagers and 60 children respectively. The subjects for the study were gotten from Federal medical center, Ido Ekiti and some selected hospitals in Ekiti state. All the antioxidants were determined using standard laboratory methods respectively. Results: The results obtained showed significant reductions (P<0.05) in the concentrations of all the antioxidants in the sickle cell subjects, at all ages - children, teenagers and adults. Conclusion: This study suggests that both enzymatic and non-enzymatic antioxidants are implicated in sickle cell anaemia irrespective of the stage and age of the carrier.

Authors and Affiliations

Oyeyemi A. O, Sonuga A. A, Oyebanji O. G

Keywords

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EP ID EP403247
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