Comparison between Two Regimens of Art in Human Immunodeficiency Virus Patients at Tertiary Care Art Centre Jabalpur: A Prospective Observational Study
Journal Title: INTERNATIONAL JOURNAL OF SCIENTIFIC STUDY - Year 2018, Vol 6, Issue 3
Abstract
Objective: The objective of the study was to assess the effectiveness of two regimens (Tenofovir + Lamivudine + Efavirenz [TLE] and Zidovudine + Lamivudine + Nevirapine [ZLN]) on the basis of CD4 count changes among human immunodeficiency virus (HIV) patients along with occurrence of adverse drug reactions (ADRs) by these regimens. Materials and Methods: A prospective observational study with a sample size of 200, divided equally into two groups of 100 each jointly conducted in the Tertiary Care ART Centre Jabalpur, from April 2016 to June 2017. Group A contains TLE regimen, and Group B contains ZLN regimen. Various ADRs were observed in both the groups. Results: Most of the patients were male (124) in our study with a maximum incidence of HIV found among 21–40 years of age group. The average increase in the CD4 count was significant only in Group A (<0.05). 83% and 93% patients of Groups A and B, show a total of 137 and 165 ADRs, respectively. Group A shows major central nervous system and gastrointestinal tract and Group B shows mainly dermatology and hematological type of ADRs. Using Modified Hartwig and Siegel severity assessment scale, we found that in Group A, ADR was mild to moderate in nature while in Group B, ADR was mainly moderate in nature. Conclusion: It was concluded that Group A containing TLE regimen was more effective as their CD4 count was significantly increase after a follow-up of 6-month treatment with least ADR and the patients who develop ADR was mainly mild in nature.
Authors and Affiliations
Rajkumari Bansal, Inder Dev Ashahiya
Keywords
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