Comparison of Dexmedetomidine And Fentanyl As Adjuvant for Wound Infiltration To Bupivacaine for Postoperative Pain Relief After Abdominal Hysterectomy
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 10
Abstract
Introduction: Several methods have been proposed to alleviate pain after hysterectomy. Local infiltration of the surgical wound is one of the important components of multimodal analgesia for post-operative pain relief. This study determines the post-operative analgesic effect of addition of dexmedetomidine and fentanyl to bupivacaine for local infiltration of the surgical wound. Methods: 40 patients with ASA class of I or II scheduled for abdominal hysterectomy were recruited for the study. The patients were randomly assigned to Group A` (control group) where patients received wound infiltration with 30 mL 0.25% bupivacaine and 25μg of fentanyl, and Group B, where patients received wound infiltration with 1.0 μg/kg dexmedetomidine diluted in 30 mL 0.25% bupivacaine. The primary objective of the study was to assess post-operative pain scores. Post-operative quality of analgesia was assessed by VAS (0-10) for 24 h and when VAS > 4 rescue analgesic was administered. Total dose of rescue analgesic and side effects were noted. They were also asked for satisfaction regarding the pain relief intervention. Results: The time of administration of first rescue analgesic was significantly higher in group B (10.52±5.54 h) as compared to group A (3.275±1.8 h). Mean VAS was significantly lower in group B as compared to group A. The total dosage of rescue analgesic was more in group A as compared to group B patients. Conclusion: Addition of dexmedetomidine to bupivacaine significantly prolonged the time to first rescue analgesic requirement and the total consumption of rescue analgesic in 24 h as compared to fentanyl added to bupivacaine.
Authors and Affiliations
Neha Kadyan, M L Khatri
Keywords
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- EP ID EP244413
- DOI 10.9790/0853-1610101114
- Views 82
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