Comparison of Efficacy of Ketoconazole and Fluconazole Incorporated into Tissue Conditioner for the Treatment of Denture Stomatitis
Journal Title: Journal of Advanced Medical and Dental Sciences Research - Year 2017, Vol 5, Issue 11
Abstract
Background: The implementation of topical antifungal therapy is difficult in geriatric patients due to multiple factors like cognitive impairment, reduced motor activity and memory loss. In addition to this maintenance of an effective topical antifungal dose in the oral cavity is difficult. These agents do not adhere and remain in contact with oral mucosa due to regular and constant wash out by the salivary flow. Aim of the study: To compare efficacy of Ketoconazole and Fluconazole incorporated into Tissue Conditioner for the treatment of denture stomatitis. Materials and methods: The present study was conducted in the Department of Prosthodontics of the Dental institution. For the study sample, we obtained clinical isolates of Candida albicans, from the Department of molecular microbiology of medical institute, to use as test organisms for the current experimental study. Tissue conditioner was mixed and prepared according to manufacturer's instruction. Antifungal agents, ketoconazole and fluconazole were mixed into tissue conditioner powder at concentrations of 5% wt/wt in a sterile plate. Results: We observed that that Ketaconazole solution was the most efficient for inhibiting attachment and colonization of C. albicans. Fluconazole solution is partially effective efficient for inhibiting attachment and colonization of C. albicans. Conclusion: The incorporation of ketoconazole or fluconazole into the tissue conditioners is effective in treatment of chronic atrophic candidiasis in denture users; however, ketoconazole was found to be more effective as compared to fluconazole
Authors and Affiliations
Mamta Sharma, Aditi Sharma, Asra Tabassum
Keywords
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