Comparison of expression of molecular markers of peripheral blood lymphocyte activation in patients with small uveal melanoma and healthy controls
Journal Title: Офтальмологический журнал - Year 2017, Vol 0, Issue 1
Abstract
Background: Organ-saving treatment is indicated for patients with small (i.e., ≤ 3 mm in prominence) uveal melanomas (UM), that being the initial stage of the disease. Association between the level of activation of the immune system and the progress of UM has been demonstrated in recent decades. Investigation of the expression of molecular markers of lymphocyte activation is important and required for predicting tumor responses to various treatments and choosing the most effective treatment for the disease. Purpose: To investigate the expression of molecular markers of peripheral blood lymphocyte activation in patients with small uveal melanomas prior to treatment. Methods: We compared the expression of molecular markers of peripheral blood lymphocyte activation in 16 patients with small uveal melanoma (prior to treatment) and 44 healthy controls (donors). Results: Prior to treatment, patients with small uveal melanoma were found to have elevated expression of molecular markers of peripheral blood lymphocyte activation compared to healthy controls (р < 0.0002). Conclusion: In uveal melanoma patients at the initial stage of the disease (i.e., with tumors ≤ 3 mm in prominence), the functional activity of immune competent cells of the body in response to tumor development was found to involve the following: (a) activation of lymphocyte IL-2 receptors (CD25+), (b) increased indices of lymphocyte activation and proliferation (CD38+, CD45+, CD150+), immunoglobulin production (CD150+), and intercellular adhesion (CD54+) and apoptosis (CD 95+), and (c) induction of cytokine secretion (CD7+).
Authors and Affiliations
S. Poliakova, L. Velichko, A. Bogdanova, I. Tsukanova
Keywords
Related Articles
- EP ID EP245053
- DOI -
- Views 113
- Downloads 0
Prevalence of ocular diseases in patients with pulmonary tuberculosis and HIV infection
Background: Given the high prevalence and rate of disability from ocular pathologies, it is clinically and socially important to determine their prevalence in patients with tuberculosis and HIV infection. Purpose: To det...
Visualization of ciliary body structures after preoperative anti-inflammatory in rhegmatogenous retinal detachment complicated by choroidal detachment
Background: Rhegmatogenous retinal detachment (RRD) can be complicated by choroidal detachment (CD). The state of the ciliary body in patients with RRD may indirectly indicate active intraocular inflammation. Purpose: T...
Axial length and refraction errors in premature infants with and without retinopathy of prematurity
Background. Preterm children, to a greater extent, can be affected by myopia in infancy and early childhood. Refractive errors can be related to the irregular growth of the eye. Purpose. To assess the incidence of ref...
Efficacy of laser stimulation of the retina with subsequent nutrient supplementation for treatment of asthenopia in students
Background. Asthenopia is a key point in information fatigue syndrome. The incidence of asthenopia syndromes (one or several) among students is 57-89.9%. The recent data have evidenced that dietary supplements with a com...
Targeted transscleral laser photocoagulation of the ciliary body in patients with neovascular glaucoma
Transscleral laser photocoagulation of the ciliary body is used to reduce intraocular pressure (IOP) in neovascular glaucoma, which is associated with a risk of complications. Purpose. To study the efficacy and safet...