Comparison of meloxicam, tamsulosin and combination of both drugs with 16 Fr and 20 Fr catheter on trial without catheter successfulness in patients with benign prostatic hyperplasia
Journal Title: Jurnal Kedokteran dan Kesehatan Indonesia - Year 2018, Vol 9, Issue 3
Abstract
Background: Acute urinary retention, is one of the main complications of Benign Prostatic Hyperplasia (BPH) in elderly patients. Trial Without Catheter (TWOC) is a way to evaluate whether a patient can urinate spontaneously after an episode of urinary retention. Objective: To prove that the combination of meloxicam 15 mg and tamsulosin 0.4 mg orally once daily for three weeks with 20 Fr catheter is more effective in the TWOC successfulness in BPH patients than meloxicam 15 mg or tamsulosin 0.4 mg alone with 16 Fr catheter. Methods: Patients BPH who had the first episode of urinary retention and fulfil the inclusion criteria were randomised. There were six treatment groups (n=6). The treatment group are meloxicam 15 mg + catheter 16 Fr (K1), combination of meloxicam 15 mg and tamsulosin 0.4 mg + catheter 16 Fr (K2), tamsulosin 0.4 mg + catheter 16 Fr (K3), meloxicam 15 mg + catheter 20 Fr (K4), combination of meloxicam 15 mg and tamsulosin 0.4 mg + catheter 20 Fr (K5), tamsulosin 0.4 mg + catheter 20 Fr (K6). For each group, drugs were given orally once daily for seven days. Efficacy of TWOC was assessed by the ability of spontaneous urinary after the first 24 hour post urethral catheter treatment, with Q-max result on uroflowmetry = 5 cc/sec and PVR = 100 cc. Result: All subjects from K1 and K4 experience a recurrent episode of urinary retention (100%), 83.3% in K3 and 66.7% in K6. In the combination group, K2 had 50% incidence of repeat urinary retention, while K5 had16.7%. From the whole group, a statistically significant difference with p <0.05 only can be found in K1 and K5 (p = 0.02). Conclusion: The combination of meloxicam 15 mg and tamsulosin 0.4 mg + 20 Fr catheter had a better effect in TWOC efficacy compared with the meloxicam 15 mg + catheter 16 Fr group.
Authors and Affiliations
Hasroni Fathurrahman, Doddy Moesbadianto Soebadi
Keywords
Related Articles
- EP ID EP438853
- DOI 10.20885/jkki.vol9.iss3.art4
- Views 110
- Downloads 0
Diphtery outbreak in Indonesia in 2017
No Abstract
Kerley a line in an 18-year-old female with acute pulmonary edema and chronic kidney disease stage V
The incidence of chronic kidney disease (CKD) continues rising recently. Chronic kidney disease is associated with many multiple complications. One of the complications related to the emergency situation is acute pulmona...
Commercializing oocytes in the era of therapeutic cloning; an extension of pro-life versus pro-choice debates
No Abstract
The effect of the onset of seizure on clock drawing test score of epilepsy patients
Background: Epilepsy is one of the causing factors of cognitive impairment which affects the patient’s quality of life. The most critical risk factor for cognitive impairment in epilepsy patients is the onset of seizure....
The association between breastfeeding technique and knowledge with exclusive breastfeeding
Background : Breastmilk is the ideal food for babies. There are various inhibiting factors for the formation of awareness of parents in providing exclusive breastfeeding for example ignorance from the mother about the im...