Comparison of Neuromuscular Blockade and Recovery Characterstics of Cisatracurium Besylate versus Atracurium Besylate in Adult Surgical Patients
Journal Title: Journal of Medical Science And clinical Research - Year 2016, Vol 4, Issue 12
Abstract
Aims: To compare neuromuscular blockade and recovery characteristics of cisatracurium and atracurium in adult patients. Methodology: 60 patients, 18-65 years, ASA class I &II for surgery under general anesthesia were randomly allocated to cis-atracurium and atracurium group. After induction agent, dose of neuromuscular blocking drug (NMBA) atracurium 0.5mg/kg loading and maintenance dose of 0.1mg/kg or cisatracurium ,0.2mg/kg and maintenance dose of 0.03mg/kg was given to the patients. The onset time was determined as the interval from the end of muscle relaxant injection until “Train of four (TOF) score 0”. Neuromuscular monitoring was carried out at every 15s to stimulate the ulnar nerve via surface electrodes. Duration from the last dose of NMBA to 25% recovery of TOF was recorded. Results: Mean Duration of action (DOA) of 1ST dose in Cisatracurium group was 61.50 minute which was significantly more as compared to 38.57 minute in Atracurium group. Recovery from last dose in Cisatracurium group was 48.73 minutes, 33.63 minutes in Atracurium group and difference was statistically significant. Conclusion: Intubating conditions were achieved faster & duration of action was longer with loading dose cisatracurium than atracurium. Between neostigmine administration and attaining a TOF ratio of 80%, time duration was shorter with cisatracurium than atracurium, when administered at TOF 25%.
Authors and Affiliations
Dr Rochana G Bakhshi
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