Comparison of Oral Pregabalin Versus Bolus Dose of Intravenous Dexmedetomidine in Attenuating the Hemodynamic responses During Laparoscopic Cholecystectomy: A Prospective Randomized double Blind Study
Journal Title: Indian Journal of Anesthesia and Analgesia - Year 2019, Vol 6, Issue 4
Abstract
Background and Aims: Laparoscopic cholecystectomy is being preferred surgery for gall bladder diseases under general anesthesia in the present era. This study was designed to compare oral pregabalin versus intravenous dexmedetomidine as premedication in attenuating the hemodynamic responses in laparoscopic cholecystectomy. Material and Method: This prospective randomized double blind study was conducted in 90 patients (ASA) grade I or II, divided into two groups of 45 each. Group P- received oral pregabalin 150 mg 1 hr prior to surgery and intravenous normal saline (0.9%). Group D- received oral placebo tab 1 hr prior to surgery and IV dexmedetomidine 1 µg/kg with normal saline. Demographic data and haemodynamic parameter like heart rate, systolic, diastolic and mean blood pressure along with oxygen saturation and end tidal CO2 were noted. Assessment of pain by visual analogue pain score (VAS) and sedation by Ramsay Sedation Scale (RSS) was done. The time to first rescue analgesic and total dose of analgesics in 24 hrs were noted. Statistical analysis was done using SPSS software (version 17, SPSS, Chicago, IL). Result: In group P significant haemodynamic response was observed at laryngoscopy, after intubation and during pneumoperitonium while in group D it was significantly attenuated (p<0.05). In group D VAS score was lower and RSS score was more as compare to group P which was statistically significant (p< 0.05). The time for first resque analgesic was earlier in group P (37.5 ± 9.30) than group D (58.06 ± 11.62) (p<0.001). Conclusion: Dexmedetomidine was found to be more effective than pregabalin in maintaining hemodynamic responses along with better postoperative analgesia and more sedation than pregabalin group.
Authors and Affiliations
Seema Partani
Keywords
Related Articles
- EP ID EP668126
- DOI 10.21088/ijaa.2349.8471.6419.49
- Views 106
- Downloads 0
Prospective Analytic Study of Airway Problems in Elective Vs Emergency Cases with a Difficult Airway
A difficult airway is not only a problem during intubation but also equally a problem postoperatively in controlling the airway and if reintubation is required. A limited research study reports are available on this sub...
Comparison of Spinal and General Anaesthesia in Patients Undergoing Caesarean Section: A Prospective Study at a Tertiary Care Teaching Hospital
Background: Cesarean section (CS) is one of the most common surgical procedures today. About 20-25% of all birth is by CS. Surgery and anesthetic technique employed has been shown to effect postoperative outcomes, specif...
To Evaluate the Efficacy of Low Dose Ketamine in Attenuating Haemodynamic Stress Response Induced by Pneumoperitoneum in Laparoscopic Cholecystectomy Under General Anaesthesia: A Prospective Study
Background: Pneumoperitoneum required for laparoscopy causes cardiovascular and pulmonary stress responses. Various pharmacological interventions have been used to attenuate those sympathetic response. N-methyl-D-asparta...
Comparative Study of LMA Supreme versus I-gel in Patients Undergoing Laparoscopic Surgeries with Positive Pressure Ventilation
Backround: The main objective of this study is to compare the efficacy of two newer supraglottic airway devices LMA Supreme and I GEL in patients undergoing laparoscopic surgeries with positive pressure ventilation. Mate...
A Comparison of the Effectiveness of Post-operative Analgesia for Single Dose Epidural 0.125% Levobupivacaine and 0.2% Ropivacaine in Patients Posted for Elective Lower Limb Surgeries
Central neuraxial blockade in the form of epidural is very popular for lower abdominal and lower limb surgeries as these techniques avoids the disadvantages associated with general anaesthesia like airway manipulation, p...