COMPARISON OF SAFETY AND EFFICACY OF LEVOSULPIRIDE AND ITOPRIDE IN TREATMENT OF GASTROESOPHAGEAL REFLUX DISEASE
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2017, Vol 4, Issue 6
Abstract
BACKGROUND Gastroesophageal Reflux Disease (GERD) is a common condition caused by reflux of the liquid acidic contents of the stomach into the oesophagus. Prokinetic medications can be used to treat or control the disease. Such medications can have mild-toserious adverse effects. Levosulpiride and itopride are two such medications, which are used for treating GERD. The aim of the study is to assess the safety and efficacy of levosulpiride and itopride in the management of GERD and to study the side effects and treatment outcome. MATERIALS AND METHODS A total 210 patients aged 18 to 90 years, 99 males and 111 females (male:female ratio of 1:1.1) with reflux oesophagitis were divided into three groups and an endoscopy test was done before starting treatment. The control group received rabeprazole and the two test groups received levosulpiride and itopride. Clinical adverse events were recorded at the end of week 1 and week 2. Following treatment, relief of symptoms was assessed at the end of 2 weeks. RESULTS There were total 210 patients (99 males and 111 females). The male-to-female ratio was 1:1.1. GERD was more common in the 31-50 year age group. Most common symptoms were of dyspepsia, regurgitation, vomiting and heartburn. Improvement of symptoms during the treatment was seen in 53% levosulpiride and 41% itopride patients, respectively. The main adverse effects were abdominal pain and nausea. The percentage of nausea was high with itopride than levosulpiride. CONCLUSION Gastroesophageal reflux disease is a common problem frequently seen in both genders and in younger people. Symptomatic relief and endoscopic recovery is early with levosulpiride than itopride. Levosulpiride gives better quality of life earlier in the treatment than itopride and has lesser side effects and better healing outcome.
Authors and Affiliations
Syed Ibrahim Hassan, Syed Mohd Akbar Hassan
Keywords
Related Articles
- EP ID EP213496
- DOI 10.18410/jebmh/2017/55
- Views 95
- Downloads 0
THE ASSOCIATION BETWEEN LOW DIASTOLIC BLOOD PRESSURE AND HIGH ATHEROSCLEROTIC VASCULAR BURDEN IN PATIENTS WITH CORONARY ARTERY DISEASE
BACKGROUND Coronary Artery Disease (CAD) has emerged as the single most important cause of death worldwide in the past decade. Hypertension, both systolic and diastolic are among the major coronary artery disease risk fa...
DISTRIBUTION OF ABO AND RH BLOOD GROUPS AMONG BLOOD DONORS AT A TERTIARY CARE HOSPITAL
BACKGROUND The ABO and Rhesus (Rh) blood group system is the most important system for blood transfusion purposes. The incidence of ABO and Rh groups varies markedly in different races, ethnic groups as well as socioecon...
A STUDY OF ASSOCIATION OF FLUOROQUINOLONES IN TENDINITIS AND ASSOCIATED COMPLICATIONS
BACKGROUND Fluoroquinolones are the quinolone antimicrobials, which are known to have one or more fluorine substitutions. The first generation fluoroquinolones, which was introduced in 1980s have one fluoro substitution....
A COMPARATIVE STUDY OF ATENOLOL AND PROPRANOLOL ON CHEMODYNAMICS AND LIPID PROFILE IN ALCOHOLIC HYPERTENSIVE PATIENTS
In developing countries particularly in India, the constitutions of the diseases, showing a fatal cause has considerably changed during the recent period. Lifestyle related diseases such as Cancer, Cardio-Vascular, Metab...
CT EVALUATION OF MEDIASTINAL MASSES
BACKGROUND The mediastinum is demarcated by the pleural cavities laterally, the thoracic inlet superiorly and the diaphragm inferiorly. It is further divided into anterior, middle and posterior compartments by many anato...