Comparison of the effects of gonadotropin-releasing hormone and raloxifeneon the size of uterine leiomyoma
Journal Title: Chronic Diseases Journal - Year 2014, Vol 2, Issue 1
Abstract
BACKGROUND: Uterine leiomyoma is a prevalent benign tumor. Several studies have shown the positive effects of raloxifene in the treatment of leiomyomas. Since raloxifene has fewer side effects than the gonadotropin-releasing hormone (GnRH) agonist, if proven effective, it can be applied easily. This study aimed to compare the medical effects of raloxifene and GnRH on uterine leiomyoma size. METHODS: This clinical trial included 53 women with uterine leiomyoma. Participants were randomly divided into 2 groups of raloxifene and GnRH. The GnRH group received 1 dose per month (intramuscular injection) and the raloxifene group received 60 mg raloxifene orally/day for 3 months. The size of the leiomyoma, prior and during the intervention, was determined by a sonographist. During the study, repeated measurement was used for comparing the trend of alterations in the tumor size. RESULTS: Analysis of changes in leiomyoma tumor size (log of tumor size) by repeated measurement showed that decrease in tumor size in the raloxifene group was significantly higher than GnRH group (P = 0.042). The trends of changes in endometrial thickness were different in the 2 groups and the reduction of thickness was more significant in the GnRH group (P = 0.026). CONCLUSION: This study showed that raloxifene is an appropriate medicine to reduce the size of uterine leiomyoma and is more effective than GnRH.
Authors and Affiliations
Farnaz Zandvakili, Fariba Seyedoshohadaie, Masoumeh Rezaiee, Nasrin Soofizade, Ebrahim Ghaderi
Keywords
Related Articles
- EP ID EP284976
- DOI -
- Views 117
- Downloads 0
Investigation of renal osteodystrophy among hemodialysis patients referring to Towhid Hospital, Sanandaj, Iran
BACKGROUND: Renal osteodystrophy is a major complication among dialysis patients that can lead to muscle weakness, and bone pain and fractures by minor trauma. In the present study, the frequency of these symptoms and st...
Stress and its related factors in families of patients with cancer
BACKGROUND: Cancer is one of the most common kinds of chronic diseases. In addition, it is a cause of stress in the family members of the patient. Therefore, the aim of this study was to determine the amount of stress an...
Association between plasma homocysteine and diabetic retinopathy in type II diabetes mellitus
BACKGROUND: Diabetic retinopathy (DR) is one of the complications occurs in patients with diabetes mellitus (DM) and is the leading cause of new onset blindness. This study aimed to determine the possible association bet...
Effect of designed self-care educational program on anxiety, stress, and depression in patients with benign prostatic hyperplasia undergoing prostate surgery
BACKGROUND: Stress, anxiety, and depression are common psychological problems in prostatic conditions. The aim of this study was to investigate the effects of designed self-care educational program on anxiety, stress, an...
Pattern of animal bites and factors associated with delay in post-exposure prophylaxis in bitten people
BACKGROUND: Since the epidemiology of animal bites and the relevant factors in post-exposure prophylaxis (PEP) are of great significance for preventing the deaths resulting from rabies and controlling the rabies disease,...