Comparison of the Effects of Topical Ebselen, Propolis and Steroid Applications on Acute Radiodermatitis: Preliminary Results
Journal Title: Journal of Academic Research in Medicine - Year 2021, Vol 11, Issue 1
Abstract
Objective: Radiodermatitis is one of the early complications of radiotherapy (RT). In an acute setting, skin changes may vary from mild hyperemia to necrosis. This study aimed to compare the effects of vaseline, mometasone furoate (MF), propolis and ebselen on acute radiodermatitis and demonstrate an alternative topical treatment method that could be suggested to reduce adverse effects. Methods: A total of 40 male Wistar-Hannover rats were separated into 4 groups with 10 members to be applied with vaseline, steroid (0.01% MF), propolis (30%) and ebselen (1%), respectively. All groups received radiation at a dose of 3,000 cGy. Following the application of RT, topical applications were applied to all groups and repeated once daily until the experiment was terminated. Skin biopsies were taken from all subjects and examined in terms of erosion, epidermis atrophy, basal layer degeneration, neovascularisation, polymorphonuclear leukocyte (PMNL) infiltration, loss of hair follicles and collagenisation. Results: The level of erosion was found to be significantly lower in the MF group. Epidermal atrophy was statistically significant lower in propolis and vaseline groups. Propolis significantly decreased basal layer degeneration compared to other treatments. Neovascularisation rates were significantly higher in vaseline and ebselen groups. No significant difference was found between groups in terms of PMNL, loss of hair follicles and collagenisation. Conclusion: Different agents with different mechanisms of action may be used according to the physiopathological progress of radiodermatitis. Data obtained in this study suggest that combined use of MF, propolis and ebselen according to erythema phases may mitigate the clinical progression of acute radiodermatitis.
Authors and Affiliations
Işıl Akgün Demir, Selami Serhat Şirvan, Seyhan Hasçiçek, Canan Özdemir, Semra Karşıdağ
Retrospective Evaluation of Patients Undergoing Cardiopulmonary Resuscitation in the Emergency Department
Objective: In this study, we aimed to investigate demographic data of patients who were arrested in an emergency department and outside the hospital, who died despite effective cardiopulmonary resuscitation (CPR), how th...
A Biomechanical Comparison of Tendon Repair with a Knotless Barbed Suture and a Conventional Monofilament Suture Material: An ex-vivo Animal Experiment
Objective: Our aim is to compare the ultimate tensile strength and stiffness of a 2/0 barbed suture and a 3/0 polypropylene monofilament suture in a porcine tendon repair model. Methods: Sixteen porcine Achilles tendons...
The Phenomenon of Acute Renal Failure in Patients with Chronic Use of Wild Tobacco
In patients with acute renal failure (ARF), the differential diagnosis may be more difficult than expected. Especially in young adults without additional diseases, it may not be considered in the diagnosis that an ARF ca...
Outcomes of Post-traumatic Stiff Elbow Arthrolysis
Objective: In this study, the results of open release surgeries performed for the stiff elbows which were caused by intrinsic, extrinsic or by combination of both factors were evaluated. Methods: Twenty-three elbows of...
SMAD4 Gene Methylation May Be Effective in Adenocarcinoma Lung Cancers
Objective: In this study, we aimed to investigate the effect of promoter region methylation of small mothers against decapentaplegic 4 (SMAD4) gene in adenoma type lung cancer cases. Adenocarcinoma and squamous type carc...