Comparison of Tranexamic acid with a combination of Traneximic acid and Mefenamic acid in reducing menstrual blood loss in ovulatory Dysfunctional uterine bleeding (DUB)
Journal Title: International Journal of Interdisciplinary and Multidisciplinary Studies (IJIMS) - Year 2016, Vol 3, Issue 2
Abstract
This study was undertaken to compare the efficacy of Tranexamic acid (TXA) with a combination of Traneximic acid and Mefenamic acid (MFA) in reducing menstrual blood loss in ovulatory Dysfunctional uterine bleeding. This study is a prospective, Interventional study performed in 150 patients of ovulatory DUB. Patients diagnosed with ovulatory DUB, with normal transvaginalsonography (n=150 patients), were included in the study. The patients were grouped into two, group T receiving tablets of 500 mg txa , three times a day from day 1 to 5 of the menstrual cycle, and group TM receiving tablets of 500 mg txa + 250 mg mfa, three times a day from day 1 to 5 of the menstrual cycle, for 3 cycles i.e. 3 months. The efficacy of the treatment in both the group was evaluated by recording the reduction in menstrual blood loss (measured by calculating pictorial blood assessment chart scores) and the improvement in post-treatment haemoglobin concentrations at 3 and 6 months follow up. 150 patients who were followed up for a period of 6 months. Out of 150 cases, 41.3% (n=62) were in the age group of 36-40 years, followed by 36% (n=54) cases in 31-35 yrs. Age group.in our study maximum number of patients were para 4 or more(n=58). Majority of cases were in category of moderate anaemia (Hb=7.1-10.0) and duration of menorrhagia was 4-6 months. Improvement in Mean Hb concentration was 27.3% gm/dl in T-GROUP.While in TM-GROUP, improvement in Mean haemoglobin concentration was 37.3% gm/dl. Which was significantly higher than T-Group (p<.01).In T-GROUP, improvement in Mean PCV was 16.16% in T-group.While in TM-GROUP, improvement in Mean PCV was 17.5% in TM-GROUP which was significantly higher than T-Group (P<.01).Improvement inMean PBAC Score was 45.06% in T-GROUP after 6 months.While in TM-Group improvement in Mean PBAC Score was 55.41% in which was significantly higher than T-group (P< .01).Out of 75 cases in T-GROUP, Only 10 (13.33%) cases were relieved from dysmenorrhea after treatment .While in TM-GROUP, 29 (38.66%) of cases were relieved from dysmenorrhea in TM-GROUP which was significantly higher.It was concluded that both Tranexamic acid alone or in combination with mefenamic acid, is effective in reducing menstrual blood loss, though the efficacy of combination therapy is more superior in Ovulatory DUB.
Authors and Affiliations
Radha Rani, Meena BS, Sukhwinder Singh, Ahilya Patel, Rajoria Lata
Keywords
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