Comparison of Various Metabolite Ratios in Intracranial Lesions: A Hospital Based Survey
Journal Title: International Journal of Medical Research Professionals - Year 2018, Vol 4, Issue 1
Abstract
Background: Despite numerous efforts no universally acceptable pathological classification of brain tumors has been proposed. Diagnosis of intracranial lesions substantially relies on the ability of the experienced professional to interpret a variety of rather indirect criteria. The aim of the present study is to compare various metabolite ratios in the intracranial lesions. Materials and Methods: The present observational and prospective study was conducted in the Dept. of Radiology, Ananta Institute of Medical Science and Research Centre, Udaipur, Rajasthan. The study was conducted for a period of two years. MRA spectroscopy was performed amongst all the patients. The area under the curve of a metabolite was considered as relative concentration (integral values) and was measured in terms of ratios. For comparison of the three groups (grades) of astrocytomas, ANOVA test was applied. Probability value (P) <0.05 was regarded as significant. Results: The study included a total of 65 subjects; out of this majority were males and rest females. The mean Cho/Cr ratio was found to be higher in the metastasis (3.48) than in the gliomas (3.27 in grade IV gliomas). However the Cho/NAA ratio in the high grade gliomas (7.96 in grade IV gliomas) was greater than in the metastasis. The mean Cho/Cr ratio in TB was 1.67 and in NCC was 1.12. The mean Cho/Cr ratio in abscess was 0.75. The mean Cho/NAA ratio in TB and Abscess was 1.08 and 0.89 respectively. The mean NAA/Cr ratio in NCC and abscess was 1.15 and 0.77 respectively. Conclusion: It can be concluded that Proton MRS helps in better tissue characterization of different brain tumors. It has a complimentary role to MR imaging not only in providing a better diagnosis, but also in directing treatment and follow up of such brain tumors.
Authors and Affiliations
Karnawat Shekhar, Apurva Vohra
Keywords
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- EP ID EP529882
- DOI 10.21276/ijmrp.2018.4.1.044
- Views 81
- Downloads 0
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