Comparison of Young and Adult Rat Models of ChemotherapyInduced Alopecia
Journal Title: Journal of Clinical and Investigative Dermatology - Year 2014, Vol 2, Issue 2
Abstract
Background: Chemotherapy-induced alopecia (CIA) is a common side effect of cancer treatment with profound psychosocial repercussions. Several young (before day 14) and adult (after 3 weeks) murine models for CIA have been developed, yet no tudy thus far has compared these models. Young models are naturally synchronized in anagen while adult models require ynchronization into anagen. Here, we compared the gross and histological features of the young versus adult models of CIA n pigmented rats. Additionally, we determined the effectiveness of heat shock treatment to prevent CIA; heat shock has not een tested before in pigmented young or adult rats. Methods: To induce synchronized anagen, adult rats were clipped during early telogen. To induce alopecia, young and adult rats received intraperitoneal injections of etoposide or yclophosphamide. Rats from each model were randomized to receive heat shock preceding chemotherapy. Alopecia was observed 10 days post-chemotherapy, and dorsal skin biopsies were analyzed for histology. Results: Upon chemotherapy, oung rats developed total alopecia, whereas adult rats developed alopecia restricted to the clipped area. Histologically, quivalent hair follicle dystrophy was observed in each model 10 days post-chemotherapy. Moreover, both the young and dult ats demonstrated areas of protection from CIA corresponding to localized heat shock pretreatment. Conclusions: Both the oung and adult rat models mimic clinical and microscopic findings of CIA. However, the young rat model, with naturally ynchronized anagen, develops total alopecia upon chemotherapy, and may be a more suitable model to screen protective ompounds.
Authors and Affiliations
Jimenez Joaquin J
Keywords
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- EP ID EP195086
- DOI 10.13188/2373-1044
- Views 114
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