Concentration of neutrophil gelatinase-associated lipocalin (NGAL) in serum obtained from different vascular areas during surgical repair of abdominal aortic aneurysm
Journal Title: Annales Academiae Medicae Silesiensis - Year 2019, Vol 73, Issue
Abstract
INTRODUCTION: Neutrophil gelatinase-associated lipocalin (NGAL) is a secretory protein found in neutrophils, endothelial cells and in various organs of the gastrointestinal, respiratory, excretory and reproductive systems. NGAL, involved in inflammatory processes in cells, is regarded to be the early indicator of renal dysfunction. The surgical repair of an abdominal aortic aneurysm (AAA) is a research model of acute kidney injury. There is iatrogenic kidney injury during that intervention. The surgical technique allows the blood from various vascular areas to be collected. MATERIAL AND METHODS: The study group consisted of 21 patients with AAA who were planned to undergo surgical treatment. The serum concentration of NGAL was determined in blood: from a peripheral vein before surgery, just before removal of the aortic clamp, 5 minutes after removal of the aortic clamp; from the renal vein prior to aorta clamping, just before removal of the aortic clamp, 5 minutes after removal of the aortic clamp; from the inferior vena cava just before removal of the aortic clamp. RESULTS: The serum concentration of NGAL in the samples obtained from the peripheral vein significantly increased after the surgery. Just before removal of the aortic clamp, a significantly higher concentration of NGAL was found in the serum obtained from the inferior vena cava compared to the renal vein. conclusionS: The increase in serum concentration of NGAL after surgical repair of AAA mainly results from a greater inflow of this cytokine into the systemic circulation from vascular areas of the lower part of body, which is ischemic due to the aortic clamp.
Authors and Affiliations
Leszek Kędzierski, Michał Kokot, Grzegorz Biolik, Damian Ziaja, Krzysztof Ziaja, Jan Duława
Keywords
Related Articles
- EP ID EP549503
- DOI 10.18794/aams/93853
- Views 104
- Downloads 0
Gitelman syndrome with early onset – a case report and literature news
INTRODUCTION: Gitelman syndrome (GS) is caused by genetic mutation resulting in dysfunction of the thiazide-sensitive sodium-chloride cotransporter located in the distal convoluted tubule. The disease usually produces th...
Disturbances of discriminative sensation in patients after ischemic and haemorrhagic stroke, illustrated with example of area of innervation of median nerve and radial nerve
INTRODUCTION One of the basic functions of the nervous system is sensation, which enables the recognition and, as a consequence, appropriate reaction to various stimuli from external and internal environments. Sensation...
Farmakodynamiczne interakcje międzylekowe na oddziale intensywnej terapii – obserwacje jednoośrodkowe i przegląd piśmiennictwa
WSTĘP: Interakcje międzylekowe (DDIs) stanowią poważne zagrożenie dla zdrowia w codziennej praktyce klinicznej na oddziale intensywnej terapii (ICU). DDI dzielą się na farmakokinetyczne i farmakodynamiczne. Celem pracy b...
Self-assessment of health-related quality of life in adults involved in regular physical activity
INTRODUCTION: The study of health-related quality of life is an indication of the tendencies of modern medical-social sciences on preventive activities related to health promotion.. Such studies supplement objective heal...
Congenital chloride diarrhea primary treated as Bartter syndrome – case report
Congenital chloride diarrhea (CCD) is a rare autosomal recessive disease. It is caused by mutations in the SLC26A3 gene which encodes the transmembrane Cl-/HCO3- exchanger, mainly expressed in the apical epithelium of th...