Concomitant Hypoparathyroidism Can Mask Vitamin D Deficiency
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2015, Vol 3, Issue 1
Abstract
Nutritional vitamin D deficiency is biochemically characterized by normal or decreased serum calcium, reduced inorganic phosphate, increased alkaline phosphatase activity, and decreased serum 25 hydroxy Vitamin D. As sequelae, the levels of parathyroid hormone increased leading to increase bone activity (resorption), which is reflected by a high alkaline phosphatase activity. In this communication, we report on four patients, with low vitamin D levels, who have variable degrees of parathyroid hormone deficiency leading to a blunted response of alkaline phosphatase activity. Although rare, hypoparathyroidism can be a cause of low to normal alkaline phosphatase activity in patients who have rickets or osteomalacia.
Authors and Affiliations
Nasir A. M. Al-Jurayyan, Hanan I. O. Al Omran, Abdulaziz N. A. Al Jurayyan, Sharifah D. A. Al Issa, Amir MI Babiker
Keywords
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