Convenient route synthesis of some new benzothiazole derivatives and their pharmacological screening as antimicrobial agents
Journal Title: Annals of Advances in Chemistry - Year 2017, Vol 1, Issue 1
Abstract
Background: The reaction of 2-(benzo]d[thiazol-2-yl)-3-oxopentanedinitrile 4 with DMF/DMA has been investigated to explore the synthetic potentialities of this novel activated nitrile in heterocyclic synthesis. Results: Pyrano, pyridino, pyrazolo, azepino and oxothiepano carbonitrile derivatives could be obtained starting from 4 and plausible mechanisms for their formations are reported. Conclusion: The newly synthesized compounds were assessed for their antimicrobial activity. Compounds 7, 10 and 12 exhibited broad spectrum antibacterial profile against the tested organisms.
Authors and Affiliations
AA Fadda, NN Soliman, A Fekri
Keywords
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- EP ID EP541733
- DOI 10.29328/journal.aac.1001004
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