Conversion therapy of hepatocellular carcinoma: some pivotal issues to be resolved
Journal Title: Journal of Surgery : Concepts & Practice - Year 2024, Vol 29, Issue 2
Abstract
Progress in the systemic therapies, represented by the molecular target therapies and immune checkpoint inhibitors (ICIs), have significantly improved the prognosis of unresectable hepatocellular carcinoma (uHCC), but long term survial remains limitted. As one of the major combination of systemic and surgical therapies, conversion therapy provides potentially curative opportunity to some uHCC patients. It is widely reported from different domestic centers.The first Chinese expert consensus about it was released in 2021. Yet at the same time, there are many key issues in the practice and theory remains to be resolved. Actively thinking, exploring and finally resolving these issues are essential for establishing and promoting the standardized theoretical system of uHCC conversion therapy.
Authors and Affiliations
Lei ZHAO, Jingtao ZHONG, Huichuan SUN
Keywords
Related Articles
- EP ID EP750948
- DOI 10.16139/j.1007-9610.2024.02.03
- Views 64
- Downloads 1
The role of ERCP in the diagnosis and treatment of chronic pancreatitis
Chronic pancreatitis (CP) is a chronic progressive disease that causes varying degrees of functional damage on pancreatic endocrine and exocrine, seriously affecting the quality of life of the patients. Endoscopic retrog...
Interpretation of the 2022 edition of “guidelines for diagnosis and management of hyperthyroidism and other causes of thyrotoxicosis in China”
“Guidelines for diagnosis and management of hyperthyroidism and other causes of thyrotoxicosis in China” (2022) (referred to as the “guidelines”) was officially published in August 2022 in the Chinese Journal of Endocrin...
Surgical process and technical points of laparoscopic sleeve gastrectomy with transit bipartition
Bariatric surgery are recognized worldwide for the treatment of morbid obesity and related comorbidities. Therapeutic guidelines have been issued from many countries. Laparoscopic sleeve gastrectomy and gastric bypass ar...
Factors influencing early using enteral nutrition in severe burn patients
[Objective] To analyze the main factors affecting early using enteral nutrition and the effect of enteral nutrition within 72 h after burning on outcomes by presenting a retrospective cohort study of 11 years of hospital...
Bedside ultrasound diagnosis and risk factors of early thromboembolism after pancreaticoduodenectomy with vein reconstruction
[Objective] To investigate the risk factors of early thromboembolism after pancreaticoduodenectomy with vein reconstruction. [Methods] The results of bedside ultrasonography and clinical data of 90 patients from Ruijin H...