Correlation between Central Corneal Thickness and Intraocular Pressure among Normal IOP, Ocular Hypertensive and Primary Open Angle Glaucoma Patients
Journal Title: MVP Journal of Medical Sciences - Year 2017, Vol 4, Issue 2
Abstract
Background: Glaucoma is an optic neuropathy characterized by a typical appearance of optic nerve head and characteristic visual field loss. The diagnosis of primary glaucoma, normal tension glaucoma and ocular hypertension is made on the basis of an IOP cut-off point of 21 mmHg. Thus, any factor that alters the value of the IOP can lead to a misclassification of the patient. There is a growing consensus that assessment of Central Corneal Thickness (CCT) has become an important element of the clinical evaluation of the glaucoma patient. This study intends to analyse the CCT trends amongst three study groups: Normal subjects; Primary Open Angle Glaucoma subjects; and Ocular Hypertension subjects. It also intends to explore the relationship between CCT and GAT IOP amongst the three study groups. Lastly, this study aims to evaluate if CCT can be used as a useful tool for prognostication of disease progression in ocular hypertensives, and for glaucoma diagnosis. Aims and Objective: 1. To study and compare the CCT amongst patients with Normal IOP, ocular hypertension and glaucoma. 2. To study and compare the correlation between CCT and IOP amongst patients with Normal IOP, ocular hypertension and glaucoma. Material and Methods: IOP was measured using Goldmann’s Applanation Tonometer and CCT was measured using the ultrasound pachymeter in 60 eyes of 30 normal subjects, 60 eyes of 30 glaucoma patients and 60 eyes of 30 ocular hypertensive patients. A correction factor based on the CCT was applied and corrected IOP values were calculated for the three cohorts. Analysis of Variance and Pearson Correlation Test was used to determine any significant difference in CCT, the correction factors and the CCT adjusted IOPs between the three groups. The study was conducted between November 2014 to November 2016. Results: There was a statistically significant difference in the mean CCT of the normals (554.38 + 17.67μm) as compared to the glaucomas (554.15 + 16.39μm) and ocular hypertensives (568.18 + 30.52 μm). Applying the described correction factor for corneal thickness, 40% of eyes with ocular hypertension were found to have a corrected IOP of 21mmHg or less. Conclusion: Increased corneal thickness in ocular hypertension may lead to an overestimation of IOP in 39% of cases. Measurement of central corneal thickness is advisable when the clinical findings do not correlate with the applanation IOP.
Authors and Affiliations
Mrunal Patil, Dhiraj Balwir, Hardik jain
Keywords
Related Articles
- EP ID EP430618
- DOI 10.18311/mvpjms/2017/v4i2/11002
- Views 135
- Downloads 0
A Study of the Haemodynamic Response to Oral Clonidine as Pre–medication in Laparoscopic Surgeries
Introduction: Laparoscopic surgery is a boon for surgeons as it reduces tissue trauma, post–operative morbidity, hospital stay and healthcare costs. However, it is not possible to perform a laparoscopic procedure unless...
Review on Management of Urethral Stricture Disease at Tertiary Care Centre
Introduction: Urethral stricture disease remains a common cause of morbidity among men. Many questions about the etiology of urethral stricture disease remain unanswered till now. This study was done in a tertiary care c...
Role of Early 2D Echocardiography in Patient with Acute Myocardial Infarction in Correlation with Electrocardiography and Clinical Presentation
Introduction: Echocardiography is noninvasive, most frequently used usually the initial imaging test to evaluate all cardiovascular disease related to structural, functional, or hemodynamic abnormality of the heart or gr...
Study of Serum Alkaline Phosphatase Levels among Psoriasis Patients and Comparative Group in Tertiary Care Institute
Background: Psoriasis is a chronic relapsing autoimmune skin disease of unknown etiology, characterised by complex alterations in epidermal growth and differentiation. Oxidative stress is a known risk factor for exacerba...
The Comparative Effects of Transdermal and Intramuscular Diclofenac for Postoperative Analgesia in Patients Undergoing Laparoscopic Cholecystectomy
Aims and Objectives: To compare the analgesic effectiveness of transdermal diclofenac patch and intramuscular diclofenac in patients undergoing laparoscopic cholecystectomy. To compare the adverse effects of transdermal...