Correlation between Corneal Sensitivity and Peripheral Neuropathy in Type 2 Diabetics Attending the Endocrinology Clinic of University of Port Harcourt Teaching Hospital (UPTH), Nigeria
Journal Title: Ophthalmology Research: An International Journal - Year 2016, Vol 6, Issue 3
Abstract
Aim: To correlate the occurrence of corneal sensory loss with peripheral neuropathy in Type 2 diabetics. Study Design: A hospital-based case control study. Place and Duration: A study conducted on type 2 diabetics attending the endocrinology clinic of University of Port Harcourt Teaching Hospital (UPTH), Rivers State, Nigeria between October 28th 2013 and February 28th 2014. Methodology: Participants were selected using consecutive allocation of type 2 diabetics as they presented to the Endocrinology Clinic of University of Port Harcourt Teaching Hospital. Diabetes-free controls were recruited simultaneously. Data of each participant was documented on standard proforma and subsequently had ocular examinations. Central corneal sensitivity was assessed using a Cochet-Bonnet Aesthesiometer, peripheral neuropathy was assessed using the Biothesiometer. Results: A total of 120 diabetics and 120 age and sex-matched controls constituted the study population. Their mean age was 55.6 ±10.5 years with an age range of 30 to 82 years (diabetics: 56.6 ±10.9 years and healthy control: 54.5 ±10.1 years). Corneal sensitivity in the right eye of diabetics was: 52.4±6.7 mm and 55.5±4.9mm in controls while that in the left eye was 51.1±9.0 mm in diabetics and 54.0±5.2 mm in control. The mean value pressure applied to the central cornea in diabetics was 0.54±0.16 gm/mm2 and 0.47±0.09 gm/mm2 in controls. The average vibration perception threshold in diabetics was 21.3±7.4 and 16.6±3.8 in control. Corneal sensitivity in diabetics with symptoms of neuropathy was 51.8±6.7 and 56.3 ±5.8 in diabetics without symptoms (p-value 0.014). The corneal sensitivity in diabetics with peripheral neuropathy-biothesiometer readings > 25 mV- was 46.5± 7.2 and 54.2 ±5.4 in diabetics without peripheral neuropathy-biothesiometer readings of <25mV (p-value <0.001). Conclusion: Corneal sensitivity was significantly lower in diabetics with peripheral neuropathy when compared to diabetics without peripheral neuropathy.
Authors and Affiliations
Rhoda D. Komolafe, Chinyere N. Pedro-Egbe, Elizabeth A. Awoyesuku
Keywords
Related Articles
- EP ID EP327517
- DOI 10.9734/OR/2016/30326
- Views 120
- Downloads 0
Detecting Visuoperceptive Defects in Adult Disabled Readers with the TETRA Analyzer™. Normative Data and Test-retest Reliability
Aims: To collect normative data in adult readers with the TETRA Analyzer™, a tool developed to detect the visuoperceptive alterations supposedly involved in dyslexia. Study Design: Epidemiological study. Place and Durati...
Acute Unilateral Intraocular Pressure (IOP) Elevation in the Emergency Room (ER): A Case Report
Aim: To present a clinical case of acute unilateral intraocular pressure (IOP) elevation in the emergency room (ER) that required a complex differential diagnosis, including acute angle closure, trauma, hypertensive uvei...
The Relationship of HLA-B27 and HLA-B51 on Non-Behcet Uveitis
Aims: The aim of this study was to investigate the relationship of human leukocyte antigen (HLA)-B27 and HLA-B51 on the clinical characteristics, demographic features, localization, laterality, treatment modalities and v...
The Effects of Post Cataract Topical Treatment on Anterior Segment Punctal Tomography: An OCT Guided Comparative Study
Purpose: To compare the short term effects of preserved prednisolone acetate to preserved nepafenac eye drops on punctum size. Methods: The punctum size (inner diameter, outer diameter and height) as well as tear meniscu...
Fast Eye Movements and Slow Eye Movements in Congenital Neurosensorial Deaf Subjects as Assessed by 2D video-Oculography™
Aims: There is evidence that the deprivation of a sensory system at early developmental stage may lead to a functional change of the remaining one(s). Even if this process has been widely studied, results are still cont...