Correlation between Herpes Simplex Virus antibody titre and Duodenal Ulcer perforation
Journal Title: Journal of Medical Science And clinical Research - Year 2018, Vol 6, Issue 10
Abstract
Background: The high incidence of duodenal ulcer and perforated duodenal ulcers in this part of the country prompted us to test the hypothesis that, duodenal ulcer perforations may be associated with Herpes simplex virus infection. There is apparent absence of risk factors in DU perforation. Also it is associated with very short duration of pre-perforation dyspepsia in a significant number of perforated duodenal ulcers. It appeared that there is a high possibility that atleast a subset of these perforations could be due to Herpes simplex virus I or 2 infections. Aim: To assess the role of Herpes Simplex Virus type I and II in duodenal- ulcer perforation. Materials and Methods: This was a case-control study with three groups of 65 patients. Controls were formed by patients with no symptoms of upper gastrointestinal diseases who were admitted for nongastrointestinal disorders. Case group again subdivided to a Second group of patients with acute duodenal ulcer perforation and a third group with chronic duodenal ulcer perforation. Results: Significant statistical difference in seropositivity for HSV I & II was found in patients with both acute and chronic duodenal perforation vs controls. (P<0.05) For both HSV I and HSV II, there was a significant association between the seropositivity rates and size of acute DU perforation. P <0.05. Statistically significant difference in seropositivity to both HSV I and HSV II was seen in NSAID users. However, in the case of alcoholics and non- alcoholics, significant difference was noticed for seropositivity to HSV I only. In the case of smokers and non-smokers, there was no significant difference in the seropositivity to HSV I and II in all cases. There was a significant trend to higher seropositivity in patients with shorter pre-perforation duration and dyspepsia, for both HSV I and HSV II. There is a trend towards higher HSV titres in perforated DU compared to controls, which is statistically significant.
Authors and Affiliations
Dr Premlal A P
Keywords
Related Articles
- EP ID EP512267
- DOI -
- Views 65
- Downloads 0
Laparoscopic Splenectomy in Patients with Haematological Disorders: A Prospective Study
Introduction: Laparoscopic splenectomy (LS) was first described by Delaitre in 1992. Since then it has become a popular treatment for benign diseases. It is considered preferred surgical procedure in cases where spleen s...
Risk factors for Osteoporosis in Women Forty Years and Above in Arar City, Kingdom of Saudi Arabia (KSA)
Introduction: Osteoporosis is a systemic skeletal disease characterized by low bone mass and micro architectural deterioration of bone tissue, with a consequent increase in bone fragility and susceptibility to fracture....
Histopathological and Cytological features of Warthin like variant of Papillary Carcinoma: A Rare case report
Papillary thyroid carcinoma is the most common cancer in thyroid malignancy. Warthin like variant is unusually rare variant of papillary thyroid carcinoma. We report a case of 35 year old female presented with swelling i...
Diminished Levels of Vitamin D and Altered Lipid Profile
Vitamin D is synthesized in the skin by exposure to sunlight and known to be involved in bone homeostasis and metabolism. Deficiency of vitamin D is one of the commonest disorders found in all age groups. It is widely pr...
A Comparative Study of Key Quality Performance Indicators in Anaesthesia and Surgery, between the Years 2013 and 2014, in Operation Theatre at Indian Spinal Injuries Centre, New Delhi
Introduction: Quality and safety indicators are used to measure and monitor the quality of the services provided to the patients. It encourages an environment of continuous and sustained quality. Clinical indicators in A...