CORRELATION BETWEEN SERUM AND FOLLICULAR FLUID ACTIVIN AND CLINICAL PREGNANCY RATES IN SUBFERTILE WOMEN UNDERGOING INTRACYTOPLASMIC SPERM INJECTION
Journal Title: World Journal of Pharmaceutical Research - Year 2017, Vol 6, Issue 11
Abstract
Background: Successful pregnancy requires an intricate succession of molecular and genetic interactions through implantation process. The “window of implantation” or “window of receptivity is a limited time that reciprocal interactions between the embryo and the uterus must be executed within it. Aim of the study: to evaluate the correlation between serum and follicualr fluid activin A and preganancy rates in subfertile women undergoing intracytoplasmic sperm injection(ICSI). Pateints and methods: This study was conducted at the High Institute for Infertility Diagnosis and Assisted Reproductive Techniques, Al- Nahrain University and Kamal Al-Samarayi IVF Center-Ministry of Health in Baghdad-Iraq. The duration of the study extended from November 2015 to September 2016.The study was designed to be prospective cohort study. The sample size was 100 sub-fertile undergoing in ICSI. Serum and follicular fluid activin A were estimated for all women and then the correlation with implantation and pregnancy rates was studied. Results: serum cycle day 2 (CD2) activin A, serum activin A at day of ova pickup (OPU), follicular activin A at day of ova pickup (OPU). All these variables were highly significantly(P<0.001) lower in polycystic ovary syndrome (PCOS) groups in comparison with non-PCOS group. serum CD activin A, serum OPU activin A, FF OPU activin A, were all significantly (P<0.05) increment in women with positive pregnancy outcome than those with negative pregnancy outcome. Conclusions: Serum and follicular fluid activin A are good predictors of better pregnancy outcome in subfertile women.
Authors and Affiliations
Dr. Saad Salih Al-Dujaily
Keywords
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