Correlation between serum uric acid level and microangiopathic complications in patients with type 2 diabetes mellitus
Journal Title: MedPulse -International Medical Journal - Year 2018, Vol 5, Issue 1
Abstract
Introduction: Diabetes is a metabolic disorder with multiple microvascular complications such as retinopathy, neuropathy and nephropathy. Hyperuricemia has been found to be associated with these microvascular complications in Southeast Asian countries, but its prevalence in South Indian diabetics is unknown. Aims and objectives: Primary objective: To identify the association between serum uric acid levels (SUA) and microangiopathic complications in patients with type-2 Diabetes Mellitus. Secondary objective: To study the association of risk factors such as age, duration of diabetes, FBS, PPBS and HbA1c with uric acid levels. Materials and Methods: 50 patients attending the medicine outpatient department or admitted in the medicine ward were interviewed and a detailed history, relevant clinical examination including BMI was carried out. FBS, PPBS, HbA1c, serum uric acid and serum creatinine were done. Assessment of microvascular complications was done using urine spot PCR for nephropathy, NCS for neuropathy and detailed fundus examination for retinopathy. Results: 50 patients with a mean age of 54.5 ± 11.5 years were included in the study of which 52% were males and 48% females. Diabetic retinopathy, nephropathy and neuropathy were found in 56%, 38% and 40% of patients respectively. Mean duration of diabetes was 8.2 ± 5.5 years. The SUA levels were found to be higher in patients with retinopathy than those without retinopathy (6.7 ± 1.6 vs 5.1 ± 1.35) mg/dl which was statistically significant (p < 0.001). A similar difference was found in patients with and without neuropathy (7.1 ± 1.5 vs 5.3 ± 1.4)mg/dl (p < 0.0001). However there was no statistically significant difference in SUA levels in patients with nephropathy. Correlation of SUA levels with other risk factors such as FBS, PPBS and HbA1c, age, duration of diabetes and BMI revealed that FBS and age had a statistically significant positive correlation with SUA (p = 0.043 and p = 0.027) respectively. Conclusion: SUA levels are higher in patients with microvascular complications of type 2 DM such as retinopathy, neuropathy and nephropathy. Further, higher FBS and increasing age are found to be associated with higher uric acid levels.
Authors and Affiliations
Sarah S Premraj, Padmanabhan K, Durga Krishnan, Mayilananthi K, Rajasekaran D, Udayashankar D
Keywords
Related Articles
- EP ID EP366000
- DOI -
- Views 105
- Downloads 0
Study of various treatment modalities used in septic abortion
Introduction: Abortion is the termination of pregnancy by any means before the fetus is sufficiently developed to survive. Any type of abortion when completed with infection it is called septic abortion. Septic abortion...
Study of diagnostic accuracy of FNAC in head neck face tumors
Introduction: FNAC is an easily done procedure with minimal incidence of complication and no risk of implantation of tumor cells (<1%). The complications are rare and bleeding or inflammatory reaction in the region of th...
A study of the risk factors of thyroid nodule and goitre at tertiary health care center
Introduction: The term “thyroid nodule” refers to a distinct lesion within the thyroid gland that is palpably or radio logically distinct from the surrounding thyroid parenchyma. Thyroid nodules are common, seen in about...
Congenital pulmonary airway malformation – hybrid lesion – a case report
Introduction: Congenital pulmonary airway malformation (CPAM) is a fetal condition usually diagnosed in the early second trimester. This is a mass of lung tissue which has proliferation of bronchial structures. The space...
The personality profile of euthymic bipolar affective disorder patients at a tertiary care centre
Objective: The purpose of this study was to study the prevalence of personality disorders (PD) in euthymic bipolar affective disorder (BPAD) patients. We also aimed to study the distribution of individual personality dis...