Correlation of sialic acid and anthropometric variables in sickle cell anaemia patients
Journal Title: International Journal of Medical and Health Research - Year 2018, Vol 4, Issue 5
Abstract
Sickle cell anaemia (SCA) is characterized by sickled red blood cells which cause micro-infarct formation, ischaemia, decreased medullary blood flow and papillary necrosis. Sickle red blood cells have been reported to have a lower than normal membrane sialic acid content resulting in an abnormal interaction between sickle red blood cells and the microvascular endothelium. This deficiency is possibly reflected in a commensurate removal of the compound from the circulation. This study was designed to assess serum sialic acid (SSA) in SCA patients and its relationship with some anthropometric variables in SCA patients. This was achieved by determining the level of sialic acid in the serum of these patients. A total of 68 asymptomatic SCA patients and 30 non sickle cell anaemia controls were used for the study. Results obtained showed that the SCA patients had a significantly (P < 0.05) lower BMI (20.85 ± 0.68kg/m2 ), higher WHR (0.89 ± 0.01) and lower sBP (111.6 ± 1.97mmHg) than the control subjects with mean BMI of 24.63 ± 0.68 kg/m2 , WHR 0.86 ± 0.01, and SBP 116.0 ± 1.86 mmHg. There was a significantly (P < 0.05) elevated plasma urea (6.43 ± 0.54mmol/L) and the serum sialic acid (1.88mmol/L) was significantly (P < 0.05) lower in the SCA patients than in the control with a plasma urea of 3.33 ± 0.16mmol/L, and SSA of 1.93 ± 0.67mmol/L. SSA was also found to be significantly (P < 0.05) higher in females (1.93 ± 0.09mmol/L) than in males (1.80 ± 0.09mmol/L). There was a negative correlation between SSA and dBP (r = - 0.03, P> 0.05) while a positive correlation was found between SSA and sBP (r = 0.05, P >0.05), BMI (r = 0.04, P > 0.05), WHR (r = 0.11, P > 0.05) and plasma creatinine (r = 0.17, P > 0.05). A significant positive correlation was found between SSA and plasma urea (r = 0.27, P< 0.05) in the SCA patients. Serum sialic acid was lower in SCA patients and it is clinically correlated with WHR, BMI, and blood pressure which are prognostic factors for cardiovascular disease. SSA is also clinically correlated with plasma urea and creatinine. SSA can therefore be used as a predictor of cardiovascular and renal complications in SCA.
Authors and Affiliations
EO Onovughakpo Sakpa, EC Oyeneke, E Ayinbuomwan, JC Anionye
Keywords
Related Articles
- EP ID EP585740
- DOI -
- Views 151
- Downloads 0
The frequency of Y chromosome microdeletions and importance of genetic counselling in infertile male: A metropolis experience
Aim: To study the incidence & type of microdeletions in patient with infertility by Y Microdeletion by Polymerase chain reaction (PCR) studies. Materials and Methods: In 763 patients aged from 21-47 years with suspicion...
Study of comparative evaluation of Atorvastatin and Salacinol (Salacia roxburghii) on BMI, Lipid profile and adiponectin in patient of chronic kidney disease with hypertension
Hippocrates in 5th century B.C blamed malfunctioning kidney tor certain signs and symptoms. Progression of renal failure is an area of Nephrology where our understanding has improved appreciably in the last century but s...
Clinical characteristics of oral mucosal pain among patients visiting a dental hospital
Background: Pain arising from mucosal lesions can be of diagnostic value and could be useful in monitoring patients and planning their treatment. Although several studies have been conducted in assessment and characteriz...
An educational interventional study to sensitise and educate medical students of Gandhi Medical College Bhopal regarding H1N1 (Swine flu) disease and its prevention
Background: H1N1 is pandemic today and our country and state are also being affected by this disease. This disease spreads through respiratory tract (coughing and sneezing).Medical students remain at a higher risk of acq...
Cerebellopontine angle epidermoid CYST: Case report
Epidermoid cysts are pearly tumors which are congenital in origin, benign, extra cerebral intradural lesions and about 40% of cases are located at cerebellopontine angle. A 27 year old female with complaints of headache,...