Correlation of Trace Elements in Patients of Chronic Liver Disease with Respect to Child- TurcottePugh Scoring System
Journal Title: Journal of Clinical and Diagnostic Research - Year 2017, Vol 11, Issue 9
Abstract
Introduction: Zinc, copper, manganese and magnesium are essential trace elements whose role in chronic liver disease and its complications is not clear. Aim: To study the concentration of these elements in patients with Chronic Liver Disease (CLD) with respect to Child-TorcottePugh (CTP) scoring. Materials and Methods: This was an observational study carried out in the Department of Medicine, JSS Hospital, Mysore, India, between October 2013 and October 2015. A total of 75 patients with cirrhosis were prospectively enrolled. Severity of liver disease was assessed based on CTP score and patients were grouped into Class A, B and C. Routine investigations were done and following trace elements were assessed in allzinc, copper, manganese and magnesium. Results: The serum concentrations of zinc decreased with severity of liver disease, and the mean difference between different severity classes was statistically significant (p<0.001). There was a significant negative correlation between zinc and CTP Score (r= -0.439; p<0.001). Copper concentration was increased in patients with more severe cirrhosis and mean level difference of copper among the CTP groups were statistically significant (p<0.001). Moreover, copper showed significant positive correlation with CTP Score (r=0.385; p<0.001). The serum levels of manganese were significantly higher in patients with CTP C class in comparison to patients with CTP A and B class (p<0.05); Manganese showed significant positive correlation with CTP Score (r=0.271; p= 0.019). The concentrations of magnesium did not differ significantly between CTP class with the mean level difference not statistically significant. Conclusion: Increasing liver dysfunction alters the metabolism of trace elements towards excess of copper and deficiency of zinc.
Authors and Affiliations
Amit Agarwal, Shilpa Avarebeel, Narendra S. Choudhary, Mohan Goudar, C. J Tejaswi
Keywords
Related Articles
- EP ID EP363006
- DOI 10.7860/JCDR/2017/26519.10655
- Views 85
- Downloads 0
Spindle Cell Tumours of the Head and Neck-A Taxonomic Review
ABSTRACT Spindle cell neoplasms of the head and neck region are relatively rare, yet there importance cannot be doubted. Spindle cells are of mesenchymal origin and constitute a part of the body’s connective tissue. Soft...
Correspondence: Predictors of Mortality in Paediatric Myocarditis
Letter to Editor
Sacroiliac Joint Mobilisation versus Transcutaneous Electrical Nerve Stimulation for Pregnancy Induced Posterior Pelvic PainA Randomised Clinical Trial
ABSTRACT Introduction: The prevalence of back pain in pregnancy is reported to be 75% especially in the last trimester, 20% of these report posterior pelvic pain. Aim: To compare the effect of Sacroiliac Joint (SIJ) mob...
Myocardial Infarction with Alkaptonuria: A Case Report
ABSTRACT Alkaptonuria is an autosomal recessive disorder due to deficiency of homogentesic acid oxidase, an important enzyme in the catabolism of aromatic amino acids. Homogentesic acid is finally converted to fumarate a...
Study of Vitamin D Receptor Gene Polymorphism (FokI, TaqI and ApaI) Among Prostate Cancer Patients in North India
Introduction: Incidence of prostate cancer is rising worldwide. Multiple factors have been suggested for the aetiology of prostate cancer including ethnic, genetic and diet. Vitamin D (calcitriol) has been shown to have...