Could Phototherapy Reverse Visual Deficits in Patients with RelapsingRemitting Multiple Sclerosis?
Journal Title: Journal of Medical Science And clinical Research - Year 2015, Vol 3, Issue 5
Abstract
Background: Multiple sclerosis is a neurodegenerative disease of the central nervous system, causing irreversible deficits of the visual pathway with unknown effective treatment. Purpose: to investigate the efficacy of two original phototherapy programs on reversing the damage caused by multiple sclerosis to the neurophysiological functions of Optic nerves. Study Design: Repeated measures randomized control trial. Materials and methods: 24 patients with relapsing-remitting multiple sclerosis, from both sexes completed the study, age 25-45 years; randomly assigned into four groups. 7 patients in the control group (1); received monthly Solu -Medrol. 6 Patients in group (2) received Solu-Medrol plus low intensity laser therapy LILT 850 nm. 6 patients in group (3) received Solu-Medrol plus broad band ultraviolet B radiation BB-UVBR (280-320 nm). 5 patients in group (4) received SoluMedrol, scanner LILT and BB-UVBR; all three groups received sessions 3 days/week for 12 sessions. Visual evoked potentials (VEP) were assessed pre-treatment, post treatment, 3 months follow up. Results: Highly significant improvement (p=.009) of the right Optic nerve was recorded in the BB-UVBR group, and was sustainable at follow up. Lesser improvements were recorded in the (LLLT+UVBR) group, VEP of the right eye showed significant improvement (p=.022). However; no statistically significant improvements were recorded between the four groups post treatment and at follow up (p≥0.05). Conclusion: BB-UVBR therapy solely has the potential to efficiently ameliorate the severity of disability status and reverse Optic neuritis, rather than LILT with a counterproductive role of the combination therapy.
Authors and Affiliations
Shimaa Abdelalim Essa
Keywords
Related Articles
- EP ID EP209070
- DOI -
- Views 70
- Downloads 0
To Study the Ocular Side Effect by Chronic Use of Steroid in Chronic Obstructive Pulmonary Disease (COPD) Patients Attending Tertiary Care Centre in North India
Objective: To study the Ocular side effect by chronic use of steroid in Chronic obstructive pulmonary disease (COPD) attending tertiary care center in north India Method: 500 COPD patients of age group 50 -90 years with...
An Interesting Case of Basal Cell Carcinoma of the Face in Xeroderma Pigmentosum– Excision and Single Pedicle Advancement Flap
Xeroderma pigmentosum (XP) is an autosomal recessive disorder characterized by extreme sensitivity to ultraviolet radiation and more than a 1,000-fold increase in the risk of cutaneous malignancy, basal cell carcinoma be...
Evaluation of Chemokine Profile in Stored Whole Blood
Bizarre immunological changes have been known to occur when whole blood is stored. This study investigated the changes that could occur in chemokine profile in whole blood stored in CPDA-1 anticoagulant/preservative for...
Associate Professor in Physiology, JNMC Sawangi (M) Wardha, DMIMSU (DU), India
ABK is the metallic based herbal medicine, no scientific testimonial exist to conform its action and potential efficacy to proof the ancient siddhars’ quotation about Ayabirunkaraja katpam which is mentioned in reputed s...
Prevention of Preterm Labour in High Risk Woman by Vaginally Administered Natural Micronized Progesterone in Tertiary Care Hospital at Muzaffarpur, Bihar
Objective: A Prospective study to evaluate the effect of Prophylactic administration of natural micronized progesterone vaginally, on the occurrence of spontaneous Preterm birth in high risk woman. Materials and Methods:...