CREATION, PHYSICAL AND CHEMICAL PROPERTIES OF ALKIL-2-((5-PHENETHYL-4-R-1,2,4- TRIAZOLE-3-YL)THIO)ACET(PROPAN,BENZ)IMIDATES
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2019, Vol 12, Issue 3
Abstract
Objective: The aim of this research was to synthesize and evaluate physical-chemical properties of 5-pheneyhyl-4-R-3-thio-1,2,4-triazole and to establish identity and structure of the synthesized compounds, namely alkil-2-((5-phenethyl-4-R-1,2,4-triazole-3-yl)thio)acet(propan,benz)imidates. Methods: As starting materials for synthesis of alkil-2-((5-phenethyl-4-R-1,2,4-triazole-3-yl)thio)acet(propan,benz)imidates, the corresponding 2-((5-phenethyl-4-R-1,2,4-triazole-3-yl)thio)aceto(propane,benzo)nitrile have been used. Synthesis has been set in the absolute alcohol medium (propanol or butanol alcohol) with chloroform, using the saturation with dry hydrogen chloride. Results: In this study, we have developed nine new compounds have been received as a result of synthetic transformations, the structure of synthesized compounds has been confirmed by modern complex of physical-chemical methods of analysis (1H NMR-spectroscopy, elemental analysis), and their individuality has been conducted on gas-liquid chromatograph Agilent 1260 Infinity HPLC equipped with a mass spectrometer Agilent 6120. Conclusion: As a result of the work, it was synthesized the new compounds of the series of alkil-2-((5-phenethyl-4-R-1,2,4-triazole-3-yl)thio) acet(propan,benz)imidates and was characterized by elemental analysis and proton nuclear magnetic resonance spectroscopic analysis.
Authors and Affiliations
IGNATOVA TATYANA, KAPLAUSHENKO ANDRIY, NAGORNA NATALIYA,, AVRAMENKO ANTONINA
Keywords
Related Articles
- EP ID EP603897
- DOI -
- Views 111
- Downloads 0
RANDOMIZED, OPEN LABEL, ACTIVE CONTROLLED STUDY TO ASSESS AND COMPARE HEALTH RELATED QUALITY OF LIFE WITH MOMETASONE & FORMOTEROL VERSUS FLUTICASONE & FORMOTEROL DRY POWDER INHALER IN MILD TO MODERATE PERSISTENT ASTHMA
ABSTRACTObjectives: The present study was under taken to assess and compare the improvement in HRQoL among mild to moderate persistent asthmabetween Mometasone & Formoterol versus Fluticasone & Formoterol using d...
ANTIMICROBIAL ACTIVITY OF AQUEOUS AND ETHANOLIC LEAF EXTRACTS OF ANACARDIUM OCCIDENTALE
Objective: The objective of this study was to evaluate the antimicrobial activity of leaves of Anacardium occidentale (A. occidentale) against microorganisms including multidrug-resistant (MDR) bacteria. Methods: Agar we...
WHEN THE “RIGHT WAS WRONGâ€: A CASE OF “MISSED NEGLIGENCEâ€
 We report a case where the operation site was marked wrongly on the right side of the scalp. It was the timely intervention of a member of the surgicalteam that the possible mishap in the form of a negligent operation...
EFFECT OF URANIUM NITRICUM IN LM POTENCIES ON REDUCTION IN CARDIOVASCULAR RISK AMONG PATIENT WITH TYPE 2 DIABETES MELLITUS
Objectives: The present study was carried to determine the reduction in cardiovascular (CV) risk among the patients with type 2 diabetes mellitus (T2DM) after treatment with homeopathic uranium nitricum in LM potencies o...
CYTOTOXIC ACTIVITY OF A MEDICINAL MANGROVE PLANT CERIOPS DECANDRA (GRIFF.) DING HOU LEAVES ON HUMAN BREAST ADENOCARCINOMA CELL LINE MCF-7
Objective: Ceriops decandra (Griff.) Ding Hou (Rhizophoraceae) is an evergreen mangrove tree widely used in folklore medicine for the treatment of several diseases. Concerning the presence of anticancer molecule in C. de...