Crescents in renal biopsies and crescentic glomerulonephritis - A 5 year study from South India
Journal Title: Pathology Update: Tropical Journal of Pathology and Microbiology - Year 2017, Vol 3, Issue 2
Abstract
Background: Crescents indicate active disease with rapidly deteriorating renal function. Many primary renal diseases can be associated with crescents, however only a few conditions presents as crescentic glomerulonephritis(CrGN) . The incidence varies in different population. Aims and objective: The aim of the study was to know the incidence of CrGN and that of crescents in various glomerulopathies along with their clinicopathological associations. Material and methods: Renal core biopsies over 5 year period were collected retrospectively from pathology archives and reviewed for crescents and CrGN. Clinical , serological, Immunoflourescence and follow up details were collected. Results: A total of 1629 renal biopsies were received. Crescents were identified in 9.69% and 2.08% were CrGN. Males and females were equally distributed. Paediatric population constituted 24%. The most common presentation was nephritic syndrome. Cellular crescents were seen in 81 cases, fibro cellular/ fibrous in 55 cases and both in 22 cases. In immune complex(IC) mediated group, lupus nephritis (LN) showed crescents in 31.7%, followed by PIGN (29.67%) and IgAN (25.2%). Vasculitis group had 79% crescents. All cases of anti GBM disease and pauci immune ANCA negative renal limited vasculitis(PI-RLV) had crescents. The most common CrGNs were anti GBM disease (100%), followed by vasculitis (37%) and PI-RLV (33%) and least in IC group (5% in PIGN and IgAN and 3.5% in LN). Complete remission was seen in 32.2%. Conclusion: Crescents in renal biopsies are not rare. Although CrGN is more common in vasculitis and anti-GBM disease, the incidence of IC-GN is more in our population and a significant number may show crescents.
Authors and Affiliations
Gayatri Ravikumar, Pritilata Rout
Keywords
Related Articles
- EP ID EP263539
- DOI 10.17511/jopm.2017.i2.18
- Views 131
- Downloads 0
Histomorphological study of chorionic villi in products of conception following first trimester abortions
Background: The common problem which occurs in first trimester of pregnancy is miscarriage. Retained products of conception are commonly received specimen for histopathological examination. Apart from confirmation of pre...
Comparative study of USG guided aspiration and non-aspiration cytology for evaluation of specimen quality and diagnostic accuracy in abdominal and pelvic lumps
Introduction: The aim of this study was to compare the efficacy of USG guided fine needle aspiration cytology (FNAC) with that of fine needle non aspiration cytology (FNNAC) in abdominal, pelvic masses. Objectives: Alth...
Rapid method of cytology diagnosis by supravital staining in FNAC of various tissue and organs
Background: Supravital staining is the staining of living tissue removed from the body, but before cessation of the chemical life of the cells. Objective: The present study has been undertaken with the aim of to assess a...
Cytological and histopathological diagnosis of a multifocal Rosai dorfman disease with involvement of Pinna– A rare case report
Rosai-Dorfman disease (RDD) is a rare lymph proliferative disorder with nodal and extranodal involvements. We are presenting this case of Rosai dorfman disease with presentation in pinna of ear and with previous history...
A rare case of Actinomycosis of the pyriform sinus mimicking malignancy
Actinomyces is a commensal in the oral cavity, digestive tract and genital tract. However invasive Actinomycosis occurs when the host immunity is breached due to local or systemic immunocompromised states. The most commo...