Critical analysis of proteinuria estimation methods in pre-eclampsia: A main research article
Journal Title: Indian Journal of Obstetrics and Gynecology Research - Year 2017, Vol 4, Issue 4
Abstract
Purpose of the study: The gold standard 24-hour urine collection method for protein estimation is inconvenient and is associated with a delay in laboratory analysis. This study was undertaken to analyse the salphosalicylic acid test, urine dip stick test, urine protein to creatinine ratio with 24-hour urine protein estimation in pre-eclampsia cases. Materials and Method: This is a comparative study and consists of a single group of 240 subjects. This study was conducted in the Department of Obstetrics and Gynecology in collaboration with the Department of Biochemistry, JIPMER, Pondicherry, India, from February 2011 to January 2014. The subjects included 240 pre-eclampsia women. A first voided morning sample was obtained for sulphosalicylic acid test, Dipstick test, urine protein and creatinine estimation, urine culture and Subsequent urine samples were collected for the 24-hour urine protein estimation. Main findings: For significant proteinuria sulphosalicylic acid test with 1+ proteinuria has sensitivity, specificity, PPV, NPV of 59%,48%,39%,67% where as 2+ has 44%, 88%, 75% and 67% respectively, dipstick test with 1+ proteinuria has sensitivity, specificity, PPV, NPV of 71%, 52%, 54%,70% where as 2+ has 49%, 87%, 75% and 69% respectively. The spot urine protein to creatinine ratio and 24-hour urine protein were significantly correlated (r=0.98; P<0.0001). The cut-off value for the protein to creatinine ratio as an indicator of protein excretion ≥300 mg/day was 0.285. The sensitivity, specificity PPV and NPV were 100%, 99.02%, 100% and 99% respectively. Conclusion: The spot urine protein to creatinine ratio is a better method for estimation of proteinuria in pre-eclampsia. Funding: No Funding body, corresponding author himself bear the necessary expenses.
Authors and Affiliations
Hanumant V. Nipanal, Susmitha Shivanna Reddy, Dilip Kumar Maurrya, Ravindra Pattanashetti Nagendra
Keywords
Related Articles
- EP ID EP315116
- DOI 10.18231/2394-2754.2017.0080
- Views 83
- Downloads 0
Evaluation of role of amino acid infusion in cases of intrauterine growth restriction: Our experience
Aim: To evaluate the effect of amino acid infusion in pregnant mothers with suspected Intra Uterine Growth Restriction diagnosed in antenatal period – whether perinatal morbidity and mortality reduced or not by this trea...
Clinicopathological profile of breast lesions at tertiary care centre: A study of 602 cases
Introduction: The aim of the study was to asses clinicopathological profile of breast lesions at tertiary care center. Material and Method: The study was conducted in department of pathology, JLN medical college, Ajmer....
Awareness and determinants of utilization of �Nischay Yan Scheme� free assured referral transportation services in rural part of West Bengal-India
Background: National Rural Health Mission introduced ‘Nischay Yan’, a free assured referral transport, since 1st April 2011 in Nadia district, West Bengal, India to reduce neonatal mortality rate (NMR). We conducted a cr...
A comparative study of sociodemographic profile and fetal outcome in teenage and adult mother
Background: Teenage pregnancy is widely recognized as one of the most complex and serious social, economic and health problems throughout the world. Teenage pregnancy is a high risk pregnancy. Outcome is less satisfactor...
Ormeloxifene- A new treatment modality in Dysfunctional Uterine Bleeding: efficacy and safety
Background/ Objective: To compare the efficacy and safety of ormeloxifene and norethisterone in the medical management of Dysfunctional Uterine Bleeding (DUB). Methods: 100 cases of DUB aged between 30 to 50years, who ha...