Crizotinib-Induced Large Bowel Perforation: A Rare Adverse Event
Journal Title: Medical Journal of Clinical Trials & Case Studies - Year 2020, Vol 4, Issue 1
Abstract
Crizotinib is a tyrosine kinase inhibitor approved for use in the treatment of anaplastic lymphoma kinase positive, advanced non-small cell lung cancer. This targeted therapy improved clinical outcome and prolonged responses. However, potentially serious adverse effects may occur. We report a case of Crizotinib-induced large bowel perforation.
Authors and Affiliations
Zenzri Y*, Daoud N, Berrazaga Y and Boussen H
Comparison of Segmental Vs Total Colectomy for Treatment of Crohn’s Disease
Background: There is debate concerning segmental resection for Crohn's disease. Segmental resection is reportedly associated with a greater rate of re-resection as compared to total colectomy. This topic is rarely covere...
Pregnancy and Pheochromocytoma
Determining the etiology of Hypertensive Disorders of Pregnancy (HDPs) is important to reduce maternal and fetal mortality. Pheochromocytoma is included in the differential diagnosis of hypertension during pregnancy, wh...
Down syndrome Provide Genetic Models and Key Roles of Human Chromosome 21 Gene Targets in the Elucidation of Molecular Pathways Associated to Cell Cycle Alterations, Leukaemia and Cancer for Development of Potential Drugs and Therapeutics
Trisomy 21 or Down syndrome, caused by the triplication of human chromosome 21, is the most frequent genetic disorder with hard impact on public health. The overdosage of genes on this chromosome determines transcription...
Unusual Penetrating, Retained Cardiac Intramural Foreign Body: Case Report
Penetrating cardiac injuries are devastating lesions that represent a major challenge with a high mortality (40-90%). Such injuries are considered a real challenge because of their unpredictable clinical course. Our case...
Journey from Chronic Hepatitis C to Non-Hodgkin’s Lymphoma: A Case Report
Non- Hodgkin’s lymphomas are diverse group of cancers of lymphocytes which mostly present as enlarged lymph nodes. Hepatitis C is both hepatotropic and lymphotropic virus and there has been a strong link between chronic...