Abstract

Abstract Non-small cell lung cancer (NSCLC) is a type of lung cancer and presently a prominent cause for death among the cancer cases globally. It includes adenocarcinoma, squamous cell carcinoma and large cell carcinoma. Because of the limitations of the conventional strategies in safety and efficacy, advancement in the respective field has occurred gradually from past to present. Surgery act as a care of standard in operable early stage NSCLC. At present, trimodality approach (surgery, radiation, chemotherapy) has gained popularity in the treatment of advance stage NSCLC. Chemotherapy is associated with chemo-resistance and it is a hindrance to achieve the success. Innovative irradiation technique and pre-chemotherapy irradiation is being effective than standard radiation therapy. Targeted therapy is now increasingly used because of its long term disease control by blocking the important pathway. Various management strategies are being used for management of NSCLC which are highlighted in this study. Radiofrequency ablation (RFA), immunotherapy, personalized therapy, gene therapy has a good impact in the effective treatment of NSCLC by increasing survival rate. The present review enwraps information about available approaches and strategies which are intended for the treatment of NSCLC.

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