Cushing Syndrome: Secondary to Squamous Cell Carcinoma of the Lung
Journal Title: Journal of Clinical and Diagnostic Research - Year 2018, Vol 12, Issue 1
Abstract
Abstract Cushing syndrome secondary to ectopic Adrenocorticotrophic (ACTH) hormone secretion is an uncommon entity mostly caused by small cell lung cancer or bronchial carcinoids. It can be characterised by absence of classical cushingoid features. Ectopic ACTH syndrome is characterised by severe and progressive hypercortisolemia. Thus, prompt identification and treatment can significantly decrease morbidity in affected patients. A 57-year-old male patient with a history of Stage 4 squamous cell cancer of the lung presented with worsening hyperglycemia and hypokalemia. Physical exam was notable for facial plethora and hypertension. Hormonal testing showed a very high serum cortisol, ACTH and 24 hours urinary free cortisol levels. MRI of the brain was normal. A diagnosis of ectopic ACTH syndrome was confirmed. The patient was started on Ketoconazole and his cortisol levels improved. The patient was discharged and eventually was lost to follow up.
Authors and Affiliations
Vishnu Vardhan Garla, Christine Oakley
Keywords
Related Articles
- EP ID EP523208
- DOI 10.7860/JCDR/2018/30883.11120
- Views 66
- Downloads 0
Comparative Evaluation of Procalcitonin and Interleukin-6 as Diagnostic and Prognostic Biomarkers for Sepsis
ABSTRACT Introduction: Diagnosis of sepsis is based on host’s systemic inflammatory response to infection including life-threatening organ dysfunction. Various biomarkers are available for diagnosis and prognostication...
Assessment of Enamel Remineralisation After Treatment with Four Different Remineralising Agents: A Scanning Electron Microscopy (SEM) Study
Introduction: Decades of research has helped to increase our knowledge of dental caries and reduce its prevalence. However, according to World Oral Health report, dental caries still remains a major dental disease. Fluor...
The Outbreak of Classic and Norwegian Type Scabies, in Mentally Handicapped Persons in a Rehabilitation Centre-Iran
ABSTRACT Introduction: Scabies is an ectoparasitic infection caused in humans by the scabies mite Sarcoptes scabiei variety hominis. Aim: The aim of this study was to detect early disease scabies, finding its risk factor...
A Curious Case of Pneumomediastinum caused after Diesel Aspiration
ABSTRACT Subcutaneous emphysema and Pneumomediastinum can occur as an uncommon complication of inhalation of irritant. It is a rare complication of hydrocarbon ingestion. There are many causative factors like oesophageal...
Comparison of Physiological Changes between Transperitoneal and Retroperitoneal Approach for Urologic Laparoscopic Surgery
ABSTRACT Introduction: Laparoscopy is increasingly being performed for urologic surgeries either through transperitoneal or retroperitoneal approach. While physiological changes during transperitoneal surgeries have been...