Cystatin C: A Marker of Renal Function
Journal Title: Journal of Enam Meical College - Year 2014, Vol 4, Issue 2
Abstract
The most widely used investigation of renal function and GFR is the measurement of serum creatinine and creatinine clearance rate. This has been extremely popular in clinical medicine despite formidable difficulties associated with its quantification and interpretation. The main pathophysiological difficulties include variations in the rates of creatinine generation and its secretion by the renal tubules. Concentration of serum creatinine is now recognized as an unreliable measure of kidney function as it is affected by age, body weight, muscle mass, race and various medications. Several equations have been developed to improve the accuracy of serum creatinine level as a measure of GFR. The most widely used in adult populations are the Cockroft-Gault equation and the abbreviated Modification of Diet in Renal Disease (MDRD) equation. Even with these equations, measurement of GFR is difficult because the equations are less accurate with higher levels of kidney function and are affected by interlaboratory variation in measuring creatinine level. In the above perspective, cystatin C concentration has become a promising marker for kidney function in both native and transplanted kidneys. Because of the possible potentiality of cystatin C to be an emerging endogenous marker for quick and accurate assessment of renal function, we have decided to review elaborately on cystatin C as a marker of renal function and to review the sensitivity and specificity of cystatin C as an endogenous marker compared to serum creatinine. Results of our review study suggest that cystatin C is a better marker of renal function compared to serum creatinine and other endogenous markers irrespective of age, sex and clinical condition.
Authors and Affiliations
Md Aminul Haque Khan, Nasreen Chowdhury, Md Mozammel Hoque
Keywords
Related Articles
- EP ID EP36198
- DOI https://doi.org/10.3329/jemc.v4i2.19680
- Views 333
- Downloads 0
Effect of Oyster mushroom in Paracetamol Induced Toxicity of Liver in Wistar albino Rats
Backgroud: Liver is an important metabolic organ. It has wide range of functions including detoxification, storage of glycogen, vitamins A, D and B12, production of several coagulation factors, growth factors such as i...
Correlation of Index Finger Length (2D) with Height, Weight and BMI in Adult Bangladeshi Male
Background: Human hand is one of the most versatile parts of the human body which plays an important role in modern medical science and evolutionary biology. By virtue of evolution and genetic arrangements, digital len...
Save Generation from Substance Abuse
Globally across cultures and throughout history man has taken substances that affect mind and alter the quality of consciousness. In the last 100 years unacceptable drug taking has been an increasing area of social c...
Acute Limb Ischemia in a 95-year-old Female
plaques in aorta, mainly in the infrarenal segment, the aorta was patent up to its bifurcation. Aboveknee amputation was done on following day after admission with subsequent disarticulation. Acute limb ischemia is a...
A 50-Year-Old Male with Dapsone Hypersensitivity Syndrome
Dapsone, diamino-diphenyl sulfone, is an antibacterial and anti-inflammatory drug which is used worldwide for treating many diseases, such as leprosy, dermatitis herpetiformis, linear IgA bullous dermatosis, chronic bul...