Cyto- and genotoxicity of selected components of composite materials and their bonding systems
Journal Title: Journal of Stomatology (Czasopismo Stomatologiczne) - Year 2009, Vol 62, Issue 4
Abstract
Introduction: Results of many studies indicate that 2-hydroxyethyl methacrylate (HEMA) and triethyleneglycol dimethacrylate (TEGDMA) may interfere with cellular homeostasis by interacting with cellular membrane or depleting intracellular level of glutathione. Both monomers increase the level of reactive oxygen species (ROS), and, in consequence, disturb the intracellular redox balance. This process can result in apoptosis induction or cell cycle delay. Methacrylate monomers can also interact with DNA. HEMA and TEGDMA can induce the formation of micronuclei and alter expression of the genes whose products are involved in the regulation of cell growth, gene expression, proliferation and differentiation, cell death, replication and DNA repair.Aim of the study: To discuss processes responsible for methacrylate monomer releasing from resin-based dental fillings, and to review mechanisms of HEMA and TEGDMA cytotoxicity and genotoxicity.Conclusion: Understanding mechanisms responsible for methacrylate monomer toxicity may help explain how these chemicals affect the human body, while improving their physical and chemical properties may contribute to protecting patients’ health.
Authors and Affiliations
Dominika Książek, Elżbieta Pawłowska, Joanna Szczepańska, Janusz Błasiak
Keywords
Related Articles
- EP ID EP57795
- DOI -
- Views 100
- Downloads 0
Ultrastrukturalny obraz powierzchni zębów u młodego dorosłego pacjenta z Dentinogenesis imperfecta typ II
Wstęp. Dentinogenesis imperfecta jest schorzeniem dziedziczonym w sposób autosomalnie dominujący. Objawem klinicznym zaburzenia Dentinogenesis imperfecta typ II (DI-II) jest opalizujący kolor zębów, których korony ulega...
Role of PAX9 and MSX1 proteins in dental development and agenesis
Introduction: The development of mammalian teeth is a complex process that encompasses a number of epithelial-mesenchymal interactions that involve transcription factors. Due to its complexity, the process is prone to di...
Symmetry of dental arches in patients with unilateral primary and secondary cleft palate
Introduction. Primary and secondary cleft palate may cause disturbances in the development of the maxilla in three spacial dimensions. Patients with this defect are usually characterised by cross-bites, pseudo Class III...
Trójwymiarowe obrazowanie w chirurgii szczękowo-twarzowej i chirurgii plastycznej
Najnowsze osiągnięcia technologiczne sprawiły, że możliwe jest zarówno obrazowanie, jak i jego analiza w technologii trójwymiarowej. Opracowano różne jej typy, takie jak cefalometria 3D, analiza morfologiczna obrazu foto...
Report on the International Scientific Conference of the Periodontological Section of the polish Dental Society Advance in the diagnostic and treatment of diseases of the periodontium and oral mucosa.