Cytokine hemoadsorption therapy - An adjuvant in the management of septic shock with multi-organ dysfunction: A case report
Journal Title: National Journal of Physiology, Pharmacy and Pharmacology - Year 2018, Vol 8, Issue 2
Abstract
Sepsis is “a life-threatening organ dysfunction caused by a dysregulated host response to infection.” Cytokine hemoadsorption is found to be effective in the management of septic shock, by reducing cytokines and other inflammatory mediators, thereby improving hemodynamics and preventing multiple organ dysfunction syndrome. Here, we report a case of 22-yearold male patient, presented with fever, vomiting, loose stools, and altered mental status since 2 weeks, was provisionally diagnosed with severe sepsis/septic shock - salmonella-induced, hepatitis B-induced acute liver failure, hemophagocytic lymphohistiocytosis, and disseminated intravascular coagulopathy. The patient was admitted in intensive care unit and started on cytokine hemoperfusion therapy for 12 h. Before cytokine hemoadsorption, he was on three inotropic supports, IV antibiotics, and other supportive measures. The patient improved symptomatically and hemodynamically within 8 h of cytokine therapy, and inotropic supports were weaned off. Here, we report a successful outcome in a case of septic shock with organ damage treated with cytokine hemoadsorbant as an adjuvant along with routine conservative management.
Authors and Affiliations
Vishnu Manohar, Shilpa Raj, Sreekrishnan T P, Gireesh Kumar K P
Keywords
Related Articles
- EP ID EP457235
- DOI 10.5455/njppp.2018.8.0728118082017
- Views 64
- Downloads 0
Antihyperglycemic effects of Cajanus cajan L. (pigeon pea) ethanolic extract on the blood glucose levels of ICR mice (Mus musculus L.)
Background: Diabetes mellitus is a metabolic disease that is usually associated with abnormalities in the metabolism of different substrates leading to high blood glucose levels (BGL). Aims and Objectives: Aims and objec...
Study of interpeak latencies of waveforms of brainstem auditory evoked potentials in normal healthy persons
Background: Auditory evoked potentials (AEPs) are very small electrical voltage potentials signal generated by a sound through the auditory pathway. Age and gender influence on the brainstem AEPs (BAEPs) deserve keen app...
Comparative analysis of sympathetic nervous system activity in pre‑menopausal and post-menopausal women
Background: Post-menopausal women suffer from various complications like autonomic dysfunction which predisposes them to cardiovascular morbidity. Decline in estrogen levels after menopause is associated with increased c...
Effect of gum arabic and Nigella sativa on T-helper1 and T-helper2 immune response in Wistar rats infected with methicillin-resistant Staphylococcus aureus
Background: The herbal medications are widely used in folk medicine for treatment of variable diseases and infection. Staphylococcus aureus (Sa) is a Gram-positive bacteria that cause severe organ affection, especially i...
Analysis of breath carbon monoxide among urban automobile drivers
Background: Air pollution caused by automobiles can pose serious health hazard due to urbanization. Carbon monoxide (CO) is one of the six criteria for air pollution related to urbanization. Urban drivers are occupationa...