Cytomegalovirus Retinitis: Current State in People with HIV-AIDS in Peru
Journal Title: Ophthalmology Research: An International Journal - Year 2015, Vol 4, Issue 1
Abstract
Purpose: To describe the incidence and progression of cytomegalovirus retinitis (CMVR) in public hospital patients from Peru. Study Design: Prospective study conducted in HIV-AIDS diagnosed patients. Place and Duration of Study: Department of Ophthalmology and Department of Tropical Medicine, Hospital Nacional Dos de Mayo, from 2004 to 2013. Methodology: Descriptive statistics were obtained for age, gender, associated disease, CMVR location and ganciclovir treatment. Data were analyzed by the Pearson Chi. Square test, Mann-Whitney test, and the two-tailed exact Fischer's Exact test. SPSS version 20.0 for Windows software program was used Results: 2627 patients were evaluated, 75 had CMVR diagnosis. Active CMVR was found in 68 eyes (90.7%). Median age at diagnosis of CMVR was 37 years (IQR 30-41 years). Median CD4 level of 25 cells/μL (IQR 12.2-57.7 cells/μL), viral load > 1000,000 in 39 (52%) patients. Median mortality rate was 7.1 deaths per 1000 PY and mean survival time from HIV diagnosis to death was 29,5 months (95% 8,7-43,0 months) and from CMVR diagnosis, 6,2 months (95% IC 2,0-8,0 months). Duration since HIV diagnosis to CMVR onset was 12 months (IQR 3-48 months). Tuberculosis (TB) was present in 23 (30.7%) patients. Incidence rate of HIV patients with CMVR was 28.2 cases per 1000 PY. 51 patients received ganciclovir: endovenous 34 (91.17%), intravitreal 6 (26.5%) and orally 4 (11.8%). Conclusion: CMVR has a high prevalence in young people with an elevated value of HIV-TB co-infection (30.7%). CMVR diagnosis was a predictor for early mortality, including highly active antiretroviral therapy (ART).
Authors and Affiliations
Bety Yáñez
Keywords
Related Articles
- EP ID EP338912
- DOI 10.9734/OR/2015/17957
- Views 98
- Downloads 0
Long-Term Results of Symmetrical and Asymmetrical Surgery for Basic-type Intermittent Exotropia in Turkish Patient
Aim: To evaluate the long-term results of symmetrical (i.e., bilateral lateral rectus recession) (BLR rec) and asymmetrical (i.e., unilateral medial rectus resection and lateral rectus recession) (R-R) surgical treatment...
Visual Outcome versus Vision Satisfaction after Intravitreal Bevasizumb Injection in Diabetic Retinopathy
Introduction: Diabetic retinopathy as an important complication of diabetes mellitus is a common cause of blindness in diabetic people. A cure or treatment is not available yet. This study was designed to investigate the...
Comparative Analysis of the Mollon-reffin Minimal Colour Vision Test in Visually ‘Normal’ and Acquired Ocular Disease
Aim: Currently a variety of different colour vision tests exist in clinical practice each with its own merits and limitations. The Ishihara test is commonly used to test for congenital deficiency, causing red-green defic...
Recurrent Radiation Retinopathy and Optic Neuropathy after Cranial Irradiation Therapy Treated by Intravitreal Bevacizumab
Purpose: To report a case of radiation retinopathy and optic neuropathy after head irradiation therapy treated by intravitreal triamcinolone and bevacizumab Methods: Case report. Case: A 38 year old woman presented with...
Comparison of Phaco Energy and Complications for Conventional Phacoemulsification and 25-gauge Phacovitrectomy Surgery
Aim: To compare cumulative dissipated energy (CED), intraoperative and postoperative complications in eyes underwent conventional phacoemulsification and 25-Gauge phacovitrectomy surgery. Study Design: Retrospective, com...