CYTOMORPHOLOGICAL DETECTION OF MALIGNANT EFFUSIONS IN NON-HODGKIN LYMPHOMA: AN INSTITUTIONAL EXPERIENCE IN A DEVELOPING COUNTRY
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2019, Vol 12, Issue 3
Abstract
Objective: Lymphomatous effusions of the body cavity may be the presenting feature or develop later as a complication of systemic disease. The detection rate of lymphoma in cytologic specimen is low, especially in the absence of clinical details and ancillary studies. The present study was carried out to identify light microscopic features that are useful in identifying lymphomas on effusion cytology. Methods: A 5-year retrospective study of all patients with fluid cytology or tissue biopsy reported as suspicious or positive for non-Hodgkin lymphoma (NHL) in a tertiary care was done. The cytology, histopathology, and immunohistochemistry slides were reviewed. Results: A total of 27 cases were included in the study. Correlation with the histopathological sections of all the positive cases revealed that the cytomorphology of the abnormal lymphoid cells was monomorphous and similar to those seen in the tissue biopsy. Mercury drop karyorrhexis when present was characteristic of lymphomatous effusions. The detection rates of large cell lymphomas are higher than low-grade counterparts. Non-lymphomatous effusions showed heterogeneous lymphoid cell population and lacked karyorrhexis. Conclusion: Lymphomas can give rise to effusions. In the absence of resources in developing countries, it is important to distinguish lymphomatous effusion from a reactive process based on morphology. Monomorphous population of the lymphoid cells and presence of mercury drop karyorrhexis are useful morphological clues in identifying a lymphomatous effusion. Further, tuberculosis is a common non-neoplastic process that can be mistaken for a low-grade NHL.
Authors and Affiliations
BHAVNA NAYAL, GEETHA V
Keywords
Related Articles
- EP ID EP603841
- DOI -
- Views 107
- Downloads 0
INVESTIGATION OF CHEMICAL COMPOSITION FROM DRYOPTERIS CHOCHLEATA (D.DON) C. CHR. (DRYOPTERIDACEAE)
ABSTRACTObjective: The present study was for the determination of bioactive volatile compounds from chloroform and ethanolic extract.Methods: For present investigation of the samples were carried out by using Shimadzu Ma...
IN VITRO STUDY OF THE BRONCHORELAXATION EFFECT OF COPTOSAPELTA FLAVESCENS KORTH. ROOT’S EXTRACT AND FRACTIONS
Objective: This study aimed to compare the bronchorelaxation effect of the methanol extract, hexane fraction, ethyl acetate fraction, and methanol fraction of Coptosapelta flavescens Korth. roots (CFRs) on the isolated b...
DETERMINATION OF BIOACTIVE COMPONENTS OF BARLERIA COURTALLICA NEES (ACANTHACEAE) BY GAS CHROMATOGRAPHY–MASS SPECTROMETRY ANALYSIS
Objective: The present investigation was carried out to determine the possible bioactive components of stem, root, and leaf of Barleria courtallica Nees using a gas chromatography–mass spectrometry (GC-MS).Methods: The...
BENEFICIAL OUTCOMES AFTER COMBINED THERAPY WITH AZATHIOPRINE AND PIOGLITAZONE IN PRECLINICAL ARTHRITIC MODELS
Objectives: The present study was designed to investigate the antioxidant and anti-arthritic activities of azathioprine-pioglitazone combination therapy to check whether it has an add on benefit over monotherapy with aza...
A SIMULTANEOUS ESTIMATION, VALIDATION AND FORCED DEGRADATION STUDIES OF 5-FLUOROURACIL AND TEGAFUR IN A PHARMACEUTICAL DOSAGE FORM USING REVERSED-PHASE HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY METHOD
Objective: The present study describes the stability indicating reversed-phase high-performance liquid chromatography (RP-HPLC) method for simultaneous estimation of 5-fluorouracil and tegafur in pharmaceutical dosage fo...