CYTOTOXIC ACTIVITY OF AVOCADO SEEDS EXTRACTS (Persea americana MILL.) ON T47D CELL LINES
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2014, Vol 5, Issue 7
Abstract
Avocado (Persea americana Mill.) is a widely grown plant that had been studied for several activities such as antioxidant and chemopreventive. The aims of this study were to analyze the secondary metabolite compounds contained in avocado seeds and to determine cytotoxic effect from aqueous and ethanolic extracts of avocado seeds against T47D breast cancer cell lines. IC50 value obtained by using MTT assay on aqueous extract, ethanolic extract, and doxorubicin hydrochloride were 560,2 µg/mL, 107,15 µg/mL and 0,26 µg/mL, respectively. Phytochemical screening test had detected the alkaloids, glycosides, phenols, and saponins as chemical groups in avocado seeds extracts.
Authors and Affiliations
Elenora Kristanty, Junie Suriawati, Joko Sulistiyo
Keywords
Related Articles
- EP ID EP142291
- DOI 10.7897/2230-8407.0507113
- Views 114
- Downloads 0
STUDIES ON ANTIMICROBIAL ACTIVITY AND PHYTOCHEMICAL ANALYSIS OF CITRUS FRUIT JUICES AGAINST SELECTED ENTERIC PATHOGENS
The present study was carried out to find out the antimicrobial activity and phytochemical study of citrus fruit juices viz. Lemon (Citrus limon) and Orange (Citrus ourantium) against medically important selected enteric...
PROCESS VALIDATION AS AN INDUSTRIAL PRACTICE
Quality is the primordial intention to any industry and its products manufactured. Recently validation has become one of the pharmaceutical industries’ most recognized and discussed subjects. Validation is the means of c...
SYNTHESIS, CHARACTERIZATION OF SOME NOVEL PYRAZOLES AND THEIR GROWTH PROMOTING ACTIVITY ON SOME FLOWERING PLANTS
A series of chlorosubstituted 4-aroylpyrazoles have been synthesized by refluxing of chlorosubstituted-3-aroylflavones and 3-alkoylchromone with phenylhydrazine hydrochloride in dioxane medium with 0.5 ml of piperidine....
PHYTOCHEMICAL INVESTIGATION OF THE ROOTS OF CALOTROPIS PROCERA (AIT.) R. BR.
Two new phytoconstituents characterized as n-tetradecanyl n-hexadec-9-enoate (n-tetradecanyl palmitoleate) (4) and 18µH – urs– 12 – en - 3β, 25 - olide (proceraursenolide) (5) have been isolated for the first time from t...
MEDICINAL PLANTS USED IN THE TREATMENT OF EPILEPSY
Epilepsy may be defined as a neuropsychological disorder, which occurs due to over discharge of neurotransmitter substance. Epilepsy differs from seizure; a seizure is the paroxysmal events due to abnormal excessive hype...