CYTOTOXICITY INVESTIGATION ON CULTURED CT3 CELLS TREATED WITH MWCNTS AND F-MWCNTS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 2
Abstract
Functionalised carbon nanotubes (f-MWCNTs), derived from Multiwalled carbon nanotubes (MWCNTs) was synthesized and examined their cytotoxicity effect in drug release applications. MWCNTs were synthesized by chemical vapor deposition over Fe -MCM-41 molecular sieves using acetylene as a carbon source. They were characterized by XRD, FT-IR, RAMAN, SEM, TEM and functionalized using H2SO4:HNO3 mixtures. The MWCNTs and f-MWCNTs were tested for “invitro” MTT assay on cultured CT3 cells at different concentrations (0, 5, 10, 15 and 20 mg/ml) for 12-72 hrs. The results confirmed that f-MWCNTs were less toxic than MWCNTs. This observation suggests the applicability of f-MWCNTs in drug release applications. For the treatment of Hyperlipidemia and cholesterol control, f-MWCNTs could be novel potential materials.
Authors and Affiliations
Malarvizhi A. , Pandurangan A.
Keywords
Related Articles
- EP ID EP161024
- DOI -
- Views 116
- Downloads 0
NANOSUSPENSION: RECENT TRENDS AND TECHNOLOGIES
With the advent of modern technologies, a large number of drugs have been discovered which have a better efficiency but their clinical application is restricted due to poor water solubility. Nearly 40 % of the drugs in t...
OVERVIEW OF IN-OFFICE BLEACHING OF VITAL TEETH
The importance of tooth whitening for patients has shown a dramatic increase in the number of products and procedures over recent years. Vital tooth bleaching refers to chair-side clinical application of a chemical solut...
HERBAL INDICATORS AS AN UPCOMING TREND IN TITREMETRIC ANALYSIS
Indicators are very special chemicals, they will change color of the solution with change in pH by adding acid or alkali. Red cabbage is actually blue in color. It will be quite blue when slice it up and add some tap wat...
PHARMACOGNOSY AND PHYTOCHEMICAL EVALUATION OF ROOTS OF ECHINOPS ECHINATUS ROXB.
The genus Echinops echinatus Roxb. belongs to family Asteraceae found in India. Commonly known Kantaphala as in Sanskrit Roots used as medicine. It is used in dyspepsia, scrofula, syphilis and fever. It is also advised t...
A STUDY OF SOCIO-ECONOMIC AND PARENTAL EDUCATIONAL BACKGROUND OF FIRST YEAR MEDICAL STUDENTS IN MEDICAL COLLEGE BHAVNGAR
Carrier selection is one of the important major question in student life. Various factors affects individual’s carrier selection. Among various factors socioeconomic status and parental educational background is most imp...