Deciphering the Role of the Barr Body in Malignancy An insight into head and neck cancer
Journal Title: Sultan Qaboos University Medical Journal - Year 2017, Vol 17, Issue 4
Abstract
X chromosome inactivation is the epitome of epigenetic regulation and long non-coding ribonucleic acid function. Te differentiation status of cells has been ascribed to X chromosome activity, with two active X chromosomes generally only observed in undifferentiated or poorly differentiated cells. Recently, several studies have indicated that the reactivation of an inactive X chromosome or X chromosome multiplication correlates with the development of malignancy; however, this concept is still controversial. Tis review sought to shed light on the role of the X chromosome in cancer development. In particular, there is a need for further exploration of the expression patterns of X-linked genes in cancer cells, especially those in head and neck squamous cell carcinoma (HNSCC), in order to identify different prognostic subpopulations with distinct clinical implications. Tis article proposes a functional relationship between the loss of the Barr body and the disproportional expression of X-linked genes in HNSCC development.
Authors and Affiliations
Deepti Sharma| Department of Oral & Maxillofacial Pathology, Christian Dental College, Ludhiana, Punjab, India, George Koshy| Department of Oral & Maxillofacial Pathology, Christian Dental College, Ludhiana, Punjab, India, Shruti Gupta| Department of Oral Anatomy, Postgraduate Institute of Dental Sciences, Rohtak, Haryana, India, Bhushan Sharma| Department of Oral & Maxillofacial Pathology, Christian Dental College, Ludhiana, Punjab, India, Sonal Grover| Department of Oral & Maxillofacial Pathology, Christian Dental College, Ludhiana, Punjab, India
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- EP ID EP14814
- DOI 10.18295/squmj.2017.17.04.003
- Views 368
- Downloads 23
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