Dehydroepiandrosterone sulfate, osteoprotegerin and its soluble ligand sRANKL and bone metabolism in girls with anorexia nervosa
Journal Title: Advances in Hygiene and Experimental Medicine - Year 2012, Vol 66, Issue 0
Abstract
Background: Only scarce data exist concerning the relationship between dehydroepiandrosterone (DHEA) and/or its sulfate form DHEAS and bone status in adolescents with anorexia nervosa (AN). Aim: We investigated whether a relationship existed between DHEAS and bone metabolism (as assessed based on serum osteocalcin [OC], and collagen type I cross-linked carboxy-terminal telopeptide [CTx]). We also aimed to establish whether the above mentioned relationship might be affected by osteoprotegerin (OPG) and its soluble ligand sRANKL. Material/Methods: Fifty-six female patients with AN and 21 healthy female subjects aged 13 to 16 years participated in the study. Serum DHEAS, OC, CTx, OPG and sRANKL were measured by ELISA. Results: Our female patients with AN demonstrated significant suppression of DHEAS and bone markers, an increase in OPG and sRANKL levels, and a reduction of the OPG/sRANKL ratio. DHEAS, CTx and the OPG/sRANKL ratio correlated positively with BMI. A significant positive correlation was also observed between DHEAS and the OPG/sRANKL ratio, OC and the OPG/sRANKL ratio, and CTx and sRANKL. The correlation was negative in the case of DHEAS and CTx, DHEAS and sRANKL, CTx and the OPG/sRANKL ratio, and sRANKL and the OPG/sRANKL ratio. Discussion/ DHEAS suppression in girls with anorexia nervosa was associated with a decrease in the levels of bone markers, an increase in OPG and sRANKL concentrations and a significant decrease in the OPG/sRANKL ratio. DHEAS suppression in girls with anorexia nervosa might have a harmful effect on their bone tissue, probably via a shift in the OPG/RANKL ratio toward a functional excess of sRANKL.
Authors and Affiliations
Zofia Ostrowska, Katarzyna Ziora, Joanna Oświęcimska, Elżbieta Świętochowska, Kinga Wołkowska-Pokrywa
Keywords
Related Articles
- EP ID EP66769
- DOI -
- Views 139
- Downloads 0
The role of the class A scavenger receptors, SR-A and MARCO, in the immune system. Part 1. The structure of receptors, their ligand binding repertoires and ability to initiate intracellular signaling
Recognition of pathogens by innate immune cells is mediated by pattern recognition receptors (PRR), which include scavenger receptors (SR). The class A SR, SR-A/CD204 and MARCO, are characterized by the presence of co...
Iryzyna – nowy mediator homeostazy energetycznej
Mięśnie szkieletowe jako organ endokrynny podczas aktywności fizycznej, wydzielają cząsteczki zwane miokinami, których ekspresja wpływa na metabolizm organizmu i komunikację między tkankami. Iryzyna – nowo odkryta adipom...
The role of the bone marrow microenvironment in the pathogenesis of multiple myeloma
Multiple myeloma (MM) is one of the most common hematologic malignancies. It remains an incurable disease, so far. The mainstay of treatment for decades was pointless therapy with cytostatic agents and immunosuppressant’...
The role of intestinal microflora and probiotic bacteria in prophylactic and development of colorectal cancer
The gut microbiota comprises a large and diverse range of microorganisms whose activities have a significant impact on health. It interacts with its host at both the local and systemic level, resulting in a broad range o...
Choroba Alzheimera a produkty degradacji białka APP. Formowanie i różnorodność form fibrylujących peptydów – wybrane aspekty
Peptydowe produkty degradacji białka APP (Amyloid Precursor Protein, APP), to najważniejsze białka w patofizjologii choroby Alzheimera (Alzheimer’s disease, AD). Choć dobrze już poznane, jednak nadal budzą zainteresowani...