Dengue Vaccine: A Road to Dengue Prevention
Journal Title: International Journal of Contemporary Medical Research - Year 2018, Vol 5, Issue 3
Abstract
Every year, thousands of deaths occur due to dengue haemorrhagic fever/dengue shock syndrome (DHF/DSS). The control of the mosquito vector, Aedes aegypti, is currently the only method available to prevent dengue infections. Since vector control strategies alone have not been able to satisfactorily achieve reduction in viral transmission, the implementation of a safe, efficacious and cost-effective dengue vaccine is of top priority in public health. However, dengue vaccine development has been complicated due to the unique and complex immunopathology of dengue. Dengue vaccines have also been challenged by critical issues like absence of suitable markers of protective immunity and lack of animal models for the disease. Dengue vaccines must provide solid and long lasting protection against all four dengue viruses in dengue-endemic countries, otherwise there is the risk of sensitising recipients to severe disease. Many candidate dengue vaccines are moving towards clinical trials in human beings. Despite various limitations, collaborative effects of World Health Organization with vaccine manufacturers and policy makers, to facilitate vaccine development, can make a safe and efficacious dengue vaccine a reality in near future.
Authors and Affiliations
Alfia Alim, Asim Sarfraz
Keywords
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