DESIGN AND DEVELOPMENT OF EUDRAGIT COATED CHITOSAN MICROSPHERES FOR COLON TARGETED DELIVERY

Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2013, Vol 2, Issue 6

Abstract

Oral route is the most convenient and preferred route but other routes for CDDS may be used. Rectal administration offers the shortest route for targeting drugs to the colon. However, reaching the proximal part of colon via rectal administration is difficult. Rectal administration can also be uncomfortable for patients and compliance may be less than optimal. Administration of glucocorticoids namely dexamethasone by oral route produce systemic side effects including adenosuppression, immunosuppression, cushinoid symptoms, and bone resorption. Thus selective delivery of drugs to the colon could not only lower the required dose but also reduce the systemic side effects caused by high doses. The aim of the present investigation was to prepare colon targeted microspheres of Dexamethasone using a combination of time and pH dependent polymer that offer protection to the drug until it leaves the stomach which is provided by pH dependent polymethacrylate polymer, Eudragit S 100 and major drug release in small intestine is avoided by providing pH independent coating of Chtosan. For preparation of colon targeted microspheres the Microspheres of dexamethasone were first prepared with pH independent polymer Chitosan then with outer layer of a pH dependent polymer Eudragit L100.

Authors and Affiliations

Srikant Bhaargava*| TIT College of Pharmacy, Bhopal, Mithun Bhowmick| TIT College of Pharmacy, Bhopal, Girijesh Kumar Pandey| TIT College of Pharmacy, Bhopal, Amit Joshi| TIT College of Pharmacy, Bhopal, Balkrishna Dubey| TIT College of Pharmacy, Bhopal

Keywords

Related Articles

Antimicrobial Resistance Pattern of Acinetobacter Baumannii Infection: A Comparative Study in Indoor and Outdoor Patients.

Acinetobacter baumannii is a ubiquitous pathogen that has emerged in the last few decades as a major cause of healthcare-associated infections and nosocomial outbreaks. Increasing antimicrobial resistance has been docu...

DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR THE DETERMINATION OF ZALTOPROFEN IN BULK AND PHARMACEUTICAL TABLET DOSAGE FORM

A new RP-HPLC method was developed and validated for determination of Zaltoprofen in bulk and tablet dosage form. The estimation was carried out on Enable C18G (250 mm ×4.6 mm, 5 μm) column using Acetonitrile and Water i...

Effect of Electromagnetic Radiations on Anxiety Related Behavior: A Review

Electromagnetic radiation (EM radiation or EMR) is a form of energy emitted and absorbed by charged particles, which exhibits wave-like behavior as it travels through space. Anxiety is a normal human emotion that everyon...

AN OVERVIEW ON CORIANDER

Coriander (botanical name: coriandrum sativum Linn), is a herbal plant also referred to as store house for bioactive compounds, belonging to the family Apiceae or umbelliferae. All the parts of this herb are valued for i...

Multiplex PCR for direct identification of Campylobacter Species in Human Stool

Background Campylobacter spp. are a major cause of bacterial gastroenteritis worldwide. Is one of the most frequently isolated bacteria from the feces of infants and children in developing countries, Conventional diagnos...

Download PDF file
  • EP ID EP2355
  • DOI -
  • Views 392
  • Downloads 25

How To Cite

Srikant Bhaargava*, Mithun Bhowmick, Girijesh Kumar Pandey, Amit Joshi, Balkrishna Dubey (2013). DESIGN AND DEVELOPMENT OF EUDRAGIT COATED CHITOSAN MICROSPHERES FOR COLON TARGETED DELIVERY. Journal of Biomedical and Pharmaceutical Research, 2(6), 1-12. https://europub.co.uk./articles/-A-2355