DESIGN AND DEVELOPMENT OF SELF EMULSIFYING DRUG DELIVERY SYSTEM OF MARAVIROC
Journal Title: World Journal of Pharmaceutical Research - Year 2019, Vol 8, Issue 8
Abstract
Self emulsifying drug delivery systems (SEDDS) are isotropic mixtures of natural or synthetic oils, solids or liquid surfactants or alternatively, one or more hydrophilic solvents, and co-solvents or co-surfactants Maraviroc SEDDS formulation when diluted with 250 times gives globule size of 110 nm and zeta potential of -5.18. There is no significant difference in globule size when diluted with medias like 0.1 N HCl and Phosphate buffer of pH 6.8). Maraviroc drug release from the SEDDS formulation was performed in 0.1 N HCl and 87.92 (± 4.78) % released within 15 minutes. In-vitro drug diffusion study in dialysis membrane showed that 80.56 ± 2.81% maraviroc diffused from the SEDDS formulation in the Phosphate buffer of pH 7.4 in five hours, whereas only 42.86 (±2.12) % released from Maraviroc suspension at the same conditions. Maraviroc SEDDS formulation can be used in the treatment of AIDS.
Authors and Affiliations
Patel Rajendra
Keywords
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