DESIGN AND EVALUATION OF A FIXED DOSE COMBINATION FORMULATION OF VALSARTAN AND METFORMIN HCl FOR BIPHASIC DRUG RELEASE: A NOVEL APPROACH TO INCREASE THERAPEUTIC EFFICACY
Journal Title: International Journal of Pharmaceutical Science and Technology - Year 2011, Vol 6, Issue 1
Abstract
The objective of the present study is to formulate a fixed dose combined drug formulation of valsartan (VAL) as an immediate release layer and metformin HCl (MHCl) as a sustained release form using bilayer tablet technology, which enables biphasic drug release for once daily dosing to get a better therapeutic efficacy. The immediate release layer was prepared using super disintegrant crospovidone and extended release layer using hydroxypropylmethylcellulose (HPMC K100M), sodium carboxy methyl cellulose and povidone K90. The physicochemical compatibility and stability of the tablets were determined by Fourier transform infrared spectroscopy (FTIR), X-ray diffractometry (XRD) and differential scanning calorimetry (DSC). Bilayer tablets were subjected to accelerated stability studies for 6 months. The in-vitro release studies indicate that bi-layer tablets effectively control the drug release. Bilayer tablets were evaluated for hardness, friability, weight variation, thickness, and drug content uniformity and subjected to in vitro drug release studies using different kinetic models. The amount of VAL and MHCl released at different time intervals were estimated by HPLC method. FTIR, XRD and DSC data for the formulations indicate good compatibility and stability. These tablets exhibit no significant change either in physical appearance or dissolution pattern after storage at accelerated condition (40±2°C / 75±5%RH) for 6 months. The results indicated that VAL and MHCl could be a potential fixed dose combination form for the simultaneous treatment of hypertension and diabetes and can be developed into suitable bilayer tablets.
Authors and Affiliations
Subas C. Dinda , Durga P. Pattanayak , Ulna L. Narayan
Keywords
Related Articles
- EP ID EP150806
- DOI -
- Views 118
- Downloads 0
DESIGN AND IN-VITRO EVALUATION OF MUCOADHESIVE BUCCAL TABLETS OF REPAGLINIDE
The goal of the present investigation was to design and evaluate mucoadhesive buccal tablet of Repaglinide for the treatment of diabetes (Type-II Diabetes mellitus). The tablets were prepared by using different polymers...
HYDROPHILIC POLYMERIC MATRIX TABLET FOR SUSTAINED DELIVERY OF LEVOFLOXACIN
Purpose of undertaken research activity is to prepare a hydrophilic matrix system based, technologically optimized, sustained release (SR) tablet of levofloxacin (1000 mg) for once-a-day dosing, having adequate physicoch...
ROLES OF FLAVONOIDS IN PLANTS
Flavonoids are the low molecular weight polyphenolic secondary metabolic compounds, universally distributed in green plant kingdom, located in cell vacuoles. Flavonoids play a variety of biological activities in plants,...
SCREENING STRATEGY FOR HIGH THROUGHPUT SELECTION OF NITRILASE PRODUCING MICROORGANISMS AND MUTANTS FOR THE PRODUCTION OF PHARMACEUTICALLY IMPORTANT DRUGS AND DRUG INTERME
The prerequisite for fully exploiting the potential of a particular biocatalyst and for the laboratory evolution studies is the requirement of a reliable and convenient high throughput screening method. The major hurdle...
Vitamin A and beta-carotene: their Anticancer Potential
Cancer modulation by nutritional variation is of utmost interest among many nutritionists and cancer researchers. Among the various micronutrients, the influences of vitamin A and beta-carotene on cancer are reviewed her...