Design and Evaluation of Mouth Dissolving Tablet of Levocetrizine Hydrochloride
Journal Title: Scholars Academic Journal of Pharmacy - Year 2014, Vol 3, Issue 1
Abstract
The purpose of this research work was to develop mouth-dissolving tablet of Levocetrizine hydrochloride. Tablet containing drug and excipients were prepared by direct compression method. Excipients in combinations were incorporated to achieve the aim. Effect of different combinations was studied to optimize the ideal formulation. Drug excipients interaction studies were carried out by FTIR spectral analysis. The tablets were evaluated for their hardness, wetting time, disintegrating time and dissolution parameters. It was concluded that the tablets having the combination of crosspovidone and microcrystalline cellulose met all the evaluation parameters and thus selected as the optimized formulation. Optimized formulation was undergone for stability testing as a parameter to predict the shelf life as per ICH guidelines and proved for its adequate shelf life. Keywords: Levocetrizine hydrochloride, Mouth dissolving tablet, Optimized formulation, ICH guidelines.
Authors and Affiliations
Anisree. G. S, Anu. V, Rauof. P, Megha V, Jouhara O. P, Abeera. C. H
Keywords
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